Neuroanatomical mechanism of cerebellar mutism after stroke

Sekwang Lee, Yoon Hye Na, Hyun Im Moon, Woo Suk Tae, Sung Bom Pyun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cerebellar mutism (CM) is a rare neurological condition characterized by lack of speech due to cerebellar lesions. CM is often reported in children. We describe a rare case of CM after spontaneous cerebellar hemorrhage. The patient showed mutism, irritability, decreased spontaneous movements and oropharyngeal apraxia. Diffusion tensor imaging revealed significant volume reduction of medial frontal projection fibers from the corpus callosum. In Tracts Constrained by UnderLying Anatomy (TRACULA) analysis, forceps major and minor and bilateral cingulum-angular bundles were not visualized. Cerebello-frontal pathway reconstructed from the FMRIB Software Library showed continuity of fibers, with decreased number of fibers on qualitative analysis. These results suggest that cerebello-frontal disconnection may be a neuroanatomical mechanism of CM. Damage of brain network between occipital lobe, cingulate and cerebellum caused by hemorrhage may also have role in the mechanism of CM in our case.

Original languageEnglish
Pages (from-to)1076-1081
Number of pages6
JournalAnnals of Rehabilitation Medicine
Volume41
Issue number6
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Mutism
Stroke
Hemorrhage
Apraxias
Occipital Lobe
Diffusion Tensor Imaging
Corpus Callosum
Surgical Instruments
Cerebellum
Anatomy
Software
Brain

Keywords

  • Akinetic mutism
  • Cerebellum
  • Diffusion tensor imaging

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Neuroanatomical mechanism of cerebellar mutism after stroke. / Lee, Sekwang; Na, Yoon Hye; Moon, Hyun Im; Tae, Woo Suk; Pyun, Sung Bom.

In: Annals of Rehabilitation Medicine, Vol. 41, No. 6, 01.12.2017, p. 1076-1081.

Research output: Contribution to journalArticle

Lee, Sekwang ; Na, Yoon Hye ; Moon, Hyun Im ; Tae, Woo Suk ; Pyun, Sung Bom. / Neuroanatomical mechanism of cerebellar mutism after stroke. In: Annals of Rehabilitation Medicine. 2017 ; Vol. 41, No. 6. pp. 1076-1081.
@article{320d8ba46a5147569eee62610c4aebaa,
title = "Neuroanatomical mechanism of cerebellar mutism after stroke",
abstract = "Cerebellar mutism (CM) is a rare neurological condition characterized by lack of speech due to cerebellar lesions. CM is often reported in children. We describe a rare case of CM after spontaneous cerebellar hemorrhage. The patient showed mutism, irritability, decreased spontaneous movements and oropharyngeal apraxia. Diffusion tensor imaging revealed significant volume reduction of medial frontal projection fibers from the corpus callosum. In Tracts Constrained by UnderLying Anatomy (TRACULA) analysis, forceps major and minor and bilateral cingulum-angular bundles were not visualized. Cerebello-frontal pathway reconstructed from the FMRIB Software Library showed continuity of fibers, with decreased number of fibers on qualitative analysis. These results suggest that cerebello-frontal disconnection may be a neuroanatomical mechanism of CM. Damage of brain network between occipital lobe, cingulate and cerebellum caused by hemorrhage may also have role in the mechanism of CM in our case.",
keywords = "Akinetic mutism, Cerebellum, Diffusion tensor imaging",
author = "Sekwang Lee and Na, {Yoon Hye} and Moon, {Hyun Im} and Tae, {Woo Suk} and Pyun, {Sung Bom}",
year = "2017",
month = "12",
day = "1",
doi = "10.5535/arm.2017.41.6.1076",
language = "English",
volume = "41",
pages = "1076--1081",
journal = "Annals of Rehabilitation Medicine",
issn = "2234-0645",
publisher = "Korean Academy of Rehabilitation Medicine (KARM)",
number = "6",

}

TY - JOUR

T1 - Neuroanatomical mechanism of cerebellar mutism after stroke

AU - Lee, Sekwang

AU - Na, Yoon Hye

AU - Moon, Hyun Im

AU - Tae, Woo Suk

AU - Pyun, Sung Bom

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Cerebellar mutism (CM) is a rare neurological condition characterized by lack of speech due to cerebellar lesions. CM is often reported in children. We describe a rare case of CM after spontaneous cerebellar hemorrhage. The patient showed mutism, irritability, decreased spontaneous movements and oropharyngeal apraxia. Diffusion tensor imaging revealed significant volume reduction of medial frontal projection fibers from the corpus callosum. In Tracts Constrained by UnderLying Anatomy (TRACULA) analysis, forceps major and minor and bilateral cingulum-angular bundles were not visualized. Cerebello-frontal pathway reconstructed from the FMRIB Software Library showed continuity of fibers, with decreased number of fibers on qualitative analysis. These results suggest that cerebello-frontal disconnection may be a neuroanatomical mechanism of CM. Damage of brain network between occipital lobe, cingulate and cerebellum caused by hemorrhage may also have role in the mechanism of CM in our case.

AB - Cerebellar mutism (CM) is a rare neurological condition characterized by lack of speech due to cerebellar lesions. CM is often reported in children. We describe a rare case of CM after spontaneous cerebellar hemorrhage. The patient showed mutism, irritability, decreased spontaneous movements and oropharyngeal apraxia. Diffusion tensor imaging revealed significant volume reduction of medial frontal projection fibers from the corpus callosum. In Tracts Constrained by UnderLying Anatomy (TRACULA) analysis, forceps major and minor and bilateral cingulum-angular bundles were not visualized. Cerebello-frontal pathway reconstructed from the FMRIB Software Library showed continuity of fibers, with decreased number of fibers on qualitative analysis. These results suggest that cerebello-frontal disconnection may be a neuroanatomical mechanism of CM. Damage of brain network between occipital lobe, cingulate and cerebellum caused by hemorrhage may also have role in the mechanism of CM in our case.

KW - Akinetic mutism

KW - Cerebellum

KW - Diffusion tensor imaging

UR - http://www.scopus.com/inward/record.url?scp=85039162921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039162921&partnerID=8YFLogxK

U2 - 10.5535/arm.2017.41.6.1076

DO - 10.5535/arm.2017.41.6.1076

M3 - Article

AN - SCOPUS:85039162921

VL - 41

SP - 1076

EP - 1081

JO - Annals of Rehabilitation Medicine

JF - Annals of Rehabilitation Medicine

SN - 2234-0645

IS - 6

ER -