Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals

Juhyun Kim, Sang Yong Jung, Kyung Lee Yeon, Sangki Park, June Seek Choi, Changjoon Lee, Hye Sun Kim, Yun Beom Choi, Peter Scheiffele, Craig H. Bailey, Eric R. Kandel, Joung Hun Kim

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Neuroligin-1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. Despite evidence for the role of neuroligin-1 in specifying excitatory synapses, the underlying molecular mechanisms and physiological consequences that neuroligin-1 may have at mature synapses of normal adult animals remain unknown. By silencing endogenous neuroligin-1 acutely in the amygdala of live behaving animals, we have found that neuroligin-1 is required for the storage of associative fear memory. Subsequent cellular physiological studies showed that suppression of neuroligin-1 reduces NMDA receptor-mediated currents and prevents the expression of long-term potentiation without affecting basal synaptic connectivity at the thalamo-amygdala pathway. These results indicate that persistent expression of neuroligin-1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

Original languageEnglish
Pages (from-to)9087-9092
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number26
DOIs
Publication statusPublished - 2008 Jul 1
Externally publishedYes

Fingerprint

Amygdala
Fear
Synapses
Neuronal Plasticity
Long-Term Memory
Long-Term Potentiation
neuroligin 1
N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Maintenance

Keywords

  • Autism
  • Neuroligin
  • Synaptic plasticity

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. / Kim, Juhyun; Jung, Sang Yong; Yeon, Kyung Lee; Park, Sangki; Choi, June Seek; Lee, Changjoon; Kim, Hye Sun; Choi, Yun Beom; Scheiffele, Peter; Bailey, Craig H.; Kandel, Eric R.; Kim, Joung Hun.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 26, 01.07.2008, p. 9087-9092.

Research output: Contribution to journalArticle

Kim, J, Jung, SY, Yeon, KL, Park, S, Choi, JS, Lee, C, Kim, HS, Choi, YB, Scheiffele, P, Bailey, CH, Kandel, ER & Kim, JH 2008, 'Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 26, pp. 9087-9092. https://doi.org/10.1073/pnas.0803448105
Kim, Juhyun ; Jung, Sang Yong ; Yeon, Kyung Lee ; Park, Sangki ; Choi, June Seek ; Lee, Changjoon ; Kim, Hye Sun ; Choi, Yun Beom ; Scheiffele, Peter ; Bailey, Craig H. ; Kandel, Eric R. ; Kim, Joung Hun. / Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 26. pp. 9087-9092.
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