Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity

Geun Hee Seol, Jokubas Ziburkus, ShiYong Huang, Lihua Song, In Tae Kim, Kogo Takamiya, Richard L. Huganir, Hey Kyoung Lee, Alfredo Kirkwood

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

Near coincidental pre- and postsynaptic action potentials induce associative long-term potentiation (LTP) or long-term depression (LTD), depending on the order of their timing. Here, we show that in visual cortex the rules of this spike-timing-dependent plasticity are not rigid, but shaped by neuromodulator receptors coupled to adenylyl cyclase (AC) and phospholipase C (PLC) signaling cascades. Activation of the AC and PLC cascades results in phosphorylation of postsynaptic glutamate receptors at sites that serve as specific "tags" for LTP and LTD. As a consequence, the outcome (i.e., whether LTP or LTD) of a given pattern of pre- and postsynaptic firing depends not only on the order of the timing, but also on the relative activation of neuromodulator receptors coupled to AC and PLC. These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity.

Original languageEnglish
Pages (from-to)919-929
Number of pages11
JournalNeuron
Volume55
Issue number6
DOIs
Publication statusPublished - 2007 Sep 20

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Type C Phospholipases
Adenylyl Cyclases
Neurotransmitter Agents
Neurotransmitter Receptor
Synaptic Potentials
Glutamate Receptors
Visual Cortex
Adrenergic Agents
Cholinergic Agents
Action Potentials
Phosphorylation

Keywords

  • MOLNEURO
  • SIGNALING

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., ... Kirkwood, A. (2007). Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity. Neuron, 55(6), 919-929. https://doi.org/10.1016/j.neuron.2007.08.013

Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity. / Seol, Geun Hee; Ziburkus, Jokubas; Huang, ShiYong; Song, Lihua; Kim, In Tae; Takamiya, Kogo; Huganir, Richard L.; Lee, Hey Kyoung; Kirkwood, Alfredo.

In: Neuron, Vol. 55, No. 6, 20.09.2007, p. 919-929.

Research output: Contribution to journalArticle

Seol, GH, Ziburkus, J, Huang, S, Song, L, Kim, IT, Takamiya, K, Huganir, RL, Lee, HK & Kirkwood, A 2007, 'Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity', Neuron, vol. 55, no. 6, pp. 919-929. https://doi.org/10.1016/j.neuron.2007.08.013
Seol, Geun Hee ; Ziburkus, Jokubas ; Huang, ShiYong ; Song, Lihua ; Kim, In Tae ; Takamiya, Kogo ; Huganir, Richard L. ; Lee, Hey Kyoung ; Kirkwood, Alfredo. / Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity. In: Neuron. 2007 ; Vol. 55, No. 6. pp. 919-929.
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