Neuroprotective constituents from the fruits of Maclura tricuspidata

Nguyen Tuan Hiep, Jaeyoung Kwon, Dong Woo Kim, Sungeun Hong, Yuanqiang Guo, Bang Yeon Hwang, Nahyun Kim, Woongchon Mar, Dongho Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cudraisoflavone L − T (1–11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5–18.6 μM. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5–11.9 μM.

Original languageEnglish
Pages (from-to)2747-2759
Number of pages13
JournalTetrahedron
Volume73
Issue number19
DOIs
Publication statusPublished - 2017 May 11

Keywords

  • Circular dichroism
  • Cudrania tricuspidata
  • Maclura tricuspidata
  • Neuroprotective activity
  • Snatzke's method

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Hiep, N. T., Kwon, J., Kim, D. W., Hong, S., Guo, Y., Hwang, B. Y., Kim, N., Mar, W., & Lee, D. (2017). Neuroprotective constituents from the fruits of Maclura tricuspidata. Tetrahedron, 73(19), 2747-2759. https://doi.org/10.1016/j.tet.2017.03.064