Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines

Zi Piao Hua, Ai Jin Shun, Sook Chun Hyang, Jae Chul Lee, Won Ki Kim

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-α and IL-6 in lipopolisaccharide-stimulated microglial cells. While wogonin reduced the activity of NF-κB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharide- stimulated production of NO and cytokines was significantly blocked by various kinds of NF-κB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the overactivation of microglial cells, possibly by inactivating NF-κB signaling pathway.

Original languageEnglish
Pages (from-to)930-936
Number of pages7
JournalArchives of pharmacal research
Volume27
Issue number9
Publication statusPublished - 2004 Sep 30

Keywords

  • Cytokine
  • Microglia
  • NF-κB
  • Neuroprotection
  • Wogonin

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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