Neuroprotective effect of wogonin

Potential roles of inflammatory cytokines

Zi Piao Hua, Ai Jin Shun, Sook Chun Hyang, Jae Chul Lee, Won-Ki Kim

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-α and IL-6 in lipopolisaccharide-stimulated microglial cells. While wogonin reduced the activity of NF-κB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharide- stimulated production of NO and cytokines was significantly blocked by various kinds of NF-κB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the overactivation of microglial cells, possibly by inactivating NF-κB signaling pathway.

Original languageEnglish
Pages (from-to)930-936
Number of pages7
JournalArchives of Pharmacal Research
Volume27
Issue number9
Publication statusPublished - 2004 Sep 30
Externally publishedYes

Fingerprint

Neuroprotective Agents
Cytokines
Acetylcysteine
Scutellaria baicalensis
Middle Cerebral Artery Infarction
Mitogen-Activated Protein Kinases
Brain Ischemia
Reperfusion
Cysteine
wogonin
Rats
Interleukin-6
Nitric Oxide
Anti-Inflammatory Agents
Antioxidants

Keywords

  • Cytokine
  • Microglia
  • Neuroprotection
  • NF-κB
  • Wogonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Neuroprotective effect of wogonin : Potential roles of inflammatory cytokines. / Hua, Zi Piao; Shun, Ai Jin; Hyang, Sook Chun; Lee, Jae Chul; Kim, Won-Ki.

In: Archives of Pharmacal Research, Vol. 27, No. 9, 30.09.2004, p. 930-936.

Research output: Contribution to journalArticle

Hua, ZP, Shun, AJ, Hyang, SC, Lee, JC & Kim, W-K 2004, 'Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines', Archives of Pharmacal Research, vol. 27, no. 9, pp. 930-936.
Hua, Zi Piao ; Shun, Ai Jin ; Hyang, Sook Chun ; Lee, Jae Chul ; Kim, Won-Ki. / Neuroprotective effect of wogonin : Potential roles of inflammatory cytokines. In: Archives of Pharmacal Research. 2004 ; Vol. 27, No. 9. pp. 930-936.
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