TY - JOUR
T1 - Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells
AU - Na, Chae Sun
AU - Hong, Seong Su
AU - Choi, Yun Hyeok
AU - Lee, Yong Ho
AU - Hong, Sun Hee
AU - Lim, Ji Youn
AU - Kang, Byeong Hoa
AU - Park, So Young
AU - Lee, Dongho
PY - 2010/7
Y1 - 2010/7
N2 - A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.
AB - A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.
KW - 7-Demethylageconyflavone A
KW - Beta-amyloid
KW - Eragrostis ferruginea
KW - Neuroprotection
KW - Poaceae
UR - http://www.scopus.com/inward/record.url?scp=77955375482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955375482&partnerID=8YFLogxK
U2 - 10.1007/s12272-010-0704-5
DO - 10.1007/s12272-010-0704-5
M3 - Article
C2 - 20661708
AN - SCOPUS:77955375482
VL - 33
SP - 999
EP - 1003
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
SN - 0253-6269
IS - 7
ER -