Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells

Chae Sun Na, Seong Su Hong, Yun Hyeok Choi, Yong Ho Lee, Sun Hee Hong, Ji Youn Lim, Byeong Hoa Kang, So Young Park, Dongho Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.

Original languageEnglish
Pages (from-to)999-1003
Number of pages5
JournalArchives of pharmacal research
Volume33
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

Keywords

  • 7-Demethylageconyflavone A
  • Beta-amyloid
  • Eragrostis ferruginea
  • Neuroprotection
  • Poaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Na, C. S., Hong, S. S., Choi, Y. H., Lee, Y. H., Hong, S. H., Lim, J. Y., Kang, B. H., Park, S. Y., & Lee, D. (2010). Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. Archives of pharmacal research, 33(7), 999-1003. https://doi.org/10.1007/s12272-010-0704-5