Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells

Chae Sun Na; Seong Su Hong; Yun Hyeok Choi; Yong Ho Lee; Sun Hee Hong; Ji Youn Lim; Byeong Hoa Kang; So Young Park; Dongho Lee

doi:10.1007/s12272-010-0704-5

Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells

Chae Sun Na, Seong Su Hong, Yun Hyeok Choi, Yong Ho Lee, Sun Hee Hong, Ji Youn Lim, Byeong Hoa Kang, So Young Park, Dongho Lee

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED₅₀ value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED₅₀ values of 58.7, 44.1, and 54.8 μM, respectively.

Original language	English
Pages (from-to)	999-1003
Number of pages	5
Journal	Archives of pharmacal research
Volume	33
Issue number	7
DOIs	https://doi.org/10.1007/s12272-010-0704-5
Publication status	Published - 2010 Jul

Keywords

7-Demethylageconyflavone A
Beta-amyloid
Eragrostis ferruginea
Neuroprotection
Poaceae

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-010-0704-5

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title = "Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells",

abstract = "A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.",

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author = "Na, {Chae Sun} and Hong, {Seong Su} and Choi, {Yun Hyeok} and Lee, {Yong Ho} and Hong, {Sun Hee} and Lim, {Ji Youn} and Kang, {Byeong Hoa} and Park, {So Young} and Dongho Lee",

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AU - Na, Chae Sun

AU - Hong, Seong Su

AU - Choi, Yun Hyeok

AU - Lee, Yong Ho

AU - Hong, Sun Hee

AU - Lim, Ji Youn

AU - Kang, Byeong Hoa

AU - Park, So Young

AU - Lee, Dongho

PY - 2010/7

Y1 - 2010/7

N2 - A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.

AB - A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.

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KW - Neuroprotection

KW - Poaceae

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Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells

Abstract

Keywords

ASJC Scopus subject areas

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