Neuroprotective effects of some plant extracts against dopamine-induced oxidative stress on neuronal cell

Uk Koo, Hak Ju Lee, Dongho Lee, Hyun Jung Lee, Ah Rom Ham, Woongchon Mar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzhemier's disease. Neuropathologically, PD is characterized by the selective loss of dopaminergic neurons. The neuronal toxicity of cytosolic excess dopamine (DA) has been described in many studies using several cell lines. In dopaminergic neurons, cytosolic excess DA is easily oxidized via monoamine oxidase (MAO)-B, tyrosinase or by auto-oxidation to produce neurotoxic metabolites such as DA quinone. So, in the present study, we induced cell death by treatment of DA (600 μM) in human neuroblastoma SH-SY5Y cell which was treated samples before 24 hr, and cell viability was measured by fluorescence activated cell sorter (FACs) analysis. Of those tested, the extracts of Poria cocos ()(whole), Gastrodia elata (rhizomes), Eucommia ulmoides ()(barks), Syneilesis palmata (whole), Acorus gramineus (rhizomes), Ligustrum japonicum (leaves) showed neuroprotective effects in dose dependent manner.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalKorean Journal of Pharmacognosy
Volume40
Issue number1
Publication statusPublished - 2009 Mar 1

Keywords

  • Dopamine
  • EC
  • FACS analysis
  • Neuroprotective effects

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

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