Neuroprotective xanthones from the root bark of Cudrania tricuspidata

Jaeyoung Kwon, Nguyen Tuan Hiep, Dong Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

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29 Citations (Scopus)

Abstract

Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.

Original languageEnglish
Pages (from-to)1893-1901
Number of pages9
JournalJournal of Natural Products
Volume77
Issue number8
DOIs
Publication statusPublished - 2014 Aug 22

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Kwon, J., Hiep, N. T., Kim, D. W., Hwang, B. Y., Lee, H. J., Mar, W., & Lee, D. (2014). Neuroprotective xanthones from the root bark of Cudrania tricuspidata. Journal of Natural Products, 77(8), 1893-1901. https://doi.org/10.1021/np500364x