Neuropsychological correlates of the P300 in patients with Alzheimer's disease

Moon-Soo Lee, Seung Hwan Lee, Eun Ok Moon, Yoon Jae Moon, Sangrae Kim, Seung Hyun Kim, In Kwa Jung

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: The P300 is a useful psychophysiological index that reflects cognitive functions; however, the relationship between P300 indices and neuropsychological tests in Alzheimer's disease (AD) patients is unclear. Methods: Thirty-one AD patients and 31 elderly normal control (NC) subjects were recruited. Age and education level were matched between the two groups. The relationship between the P300 and the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) assessment packet (including 11 neuropsychological tests) was examined in AD patients. Results: Compared to the NC subjects, the AD patients exhibited significantly decreased P300 amplitudes; however, there was no significant difference between the two groups in terms of P300 latency. After a permutation-based correction for multiple tests, P300 amplitudes at the Cz and Pz electrodes were significantly correlated with performance on the word list recognition, constructional praxis, and word fluency neuropsychological tests in the AD patients. Additionally, P300 latencies at the Pz and C6 electrodes were also significantly correlated with performance on the Mini-Mental State Examination, CERAD-K version (MMSE-K), and Trail Making Test part A (TMT-A) neuropsychological tests in the AD patients. Conclusions: The results suggest that the P300 is responsive to the deterioration of language, memory, and executive functions observed in AD patients. Although there was no significant difference between the AD patients and NC subjects in the P300 latency, P300 latency has been shown to reflect impaired global cognition and attention deficits associated with AD. Our results suggest that P300 indices could be used as biological markers that indicate impaired neuropsychological functions in AD patients.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume40
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Alzheimer Disease
Neuropsychological Tests
Cognition
Electrodes
Trail Making Test
Executive Function
Registries
Language
Biomarkers
Education

Keywords

  • Alzheimer's disease
  • Biological marker
  • Neuropsychological function
  • P300

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Neuropsychological correlates of the P300 in patients with Alzheimer's disease. / Lee, Moon-Soo; Lee, Seung Hwan; Moon, Eun Ok; Moon, Yoon Jae; Kim, Sangrae; Kim, Seung Hyun; Jung, In Kwa.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 40, No. 1, 01.01.2013, p. 62-69.

Research output: Contribution to journalArticle

Lee, Moon-Soo ; Lee, Seung Hwan ; Moon, Eun Ok ; Moon, Yoon Jae ; Kim, Sangrae ; Kim, Seung Hyun ; Jung, In Kwa. / Neuropsychological correlates of the P300 in patients with Alzheimer's disease. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013 ; Vol. 40, No. 1. pp. 62-69.
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abstract = "Objectives: The P300 is a useful psychophysiological index that reflects cognitive functions; however, the relationship between P300 indices and neuropsychological tests in Alzheimer's disease (AD) patients is unclear. Methods: Thirty-one AD patients and 31 elderly normal control (NC) subjects were recruited. Age and education level were matched between the two groups. The relationship between the P300 and the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) assessment packet (including 11 neuropsychological tests) was examined in AD patients. Results: Compared to the NC subjects, the AD patients exhibited significantly decreased P300 amplitudes; however, there was no significant difference between the two groups in terms of P300 latency. After a permutation-based correction for multiple tests, P300 amplitudes at the Cz and Pz electrodes were significantly correlated with performance on the word list recognition, constructional praxis, and word fluency neuropsychological tests in the AD patients. Additionally, P300 latencies at the Pz and C6 electrodes were also significantly correlated with performance on the Mini-Mental State Examination, CERAD-K version (MMSE-K), and Trail Making Test part A (TMT-A) neuropsychological tests in the AD patients. Conclusions: The results suggest that the P300 is responsive to the deterioration of language, memory, and executive functions observed in AD patients. Although there was no significant difference between the AD patients and NC subjects in the P300 latency, P300 latency has been shown to reflect impaired global cognition and attention deficits associated with AD. Our results suggest that P300 indices could be used as biological markers that indicate impaired neuropsychological functions in AD patients.",
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