Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy

Da Eun Jung, Rita Yu, Jung Rim Yoon, Baik-Lin Eun, Soon Hak Kwon, Yun Jin Lee, So-Hee Eun, Joon Soo Lee, Heung Dong Kim, Sang Ook Nam, Gun Ha Kim, Su Kyeong Hwang, Soyong Eom, Dae Ryong Kang, Hoon Chul Kang

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Abstract

Objective: To prospectively evaluate the neuropsychological effect of levetiracetam (LVT) in comparison with carbamazepine (CBZ) and its efficacy and tolerability as a monotherapy in children with focal epilepsy. Methods: A total of 121 out of 135 screened children (4-16 years) were randomly assigned to LVT or CBZ groups in a multicenter, parallel-group, open-label trial. The study's primary endpoints were defined as the end of 52 weeks of treatment, followed by analysis of changes observed in a series of follow-up neurocognitive, behavioral, and emotional function tests performed during treatment in the per protocol population. Drug efficacy and tolerability were also analyzed among the intention-to-treat (ITT) population (ClinicalTrials.gov, number NCT02208492). Results: Eighty-one patients (41 LVT, 40 CBZ) from the randomly assigned ITT population of 121 children (57 LVT, 64 CBZ) were followed up to their last visit. No significant worsening or differences were noted between groups in neuropsychological tests, except for the Children's Depression Inventory (LVT-1.97 vs CBZ +1.43, p 0.027, [+] improvement of function). LVT-treated patients showed an improvement (p 0.004) in internalizing behavioral problems on the Korean Child Behavior Checklist. Seizure-free outcomes were not different between the 2 groups (CBZ 57.8% vs LVT 66.7%, p 0.317). Conclusions: Neither LVT nor CBZ adversely affected neuropsychological function in pediatric patients. Both medications were considered equally safe and effective as monotherapy in children with focal epilepsy. Classification of evidence: This study provides Class II evidence that in patients with pediatric focal epilepsy, LVT and CBZ exhibit equivalent effects on neuropsychological function.

Original languageEnglish
Pages (from-to)2312-2319
Number of pages8
JournalNeurology
Volume84
Issue number23
DOIs
Publication statusPublished - 2015 Jan 1

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Jung, D. E., Yu, R., Yoon, J. R., Eun, B-L., Kwon, S. H., Lee, Y. J., Eun, S-H., Lee, J. S., Kim, H. D., Nam, S. O., Kim, G. H., Hwang, S. K., Eom, S., Kang, D. R., & Kang, H. C. (2015). Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy. Neurology, 84(23), 2312-2319. https://doi.org/10.1212/WNL.0000000000001661