Newer antidepressant drug use in East Asian psychiatric treatment settings: REAP (Research on East Asia Psychotropic Prescriptions) study

Kang Sim, N. B. Lee, Hong C. Chua, Rathi Mahendran, Senta Fujii, Shu Yu Yang, Mian Yoon Chong, Tianmei Si, Yan L. He, Min-Soo Lee, Kil M. Sung, Eun K. Chung, Yiong H. Chan, Naotaka Shinfuku, Chay H. Tan, Norman Sartorius, Ross J. Baldessarini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Aims: Antidepressant use in East Asia is poorly documented. We compared patients given newer and older antidepressants to test the hypothesis, suggested in the literature, that use of newer antidepressants is associated with treatment settings rather than specific diagnostic categories. Methods: We compared rates of use of older (pre1990) vs. newer antidepressants among 1898 patients identified as antidepressant treated at 21 centres in five East Asian countries (China, Japan, Korea, Singapore, Taiwan) in 2003. Demographics, treatment setting and clinical factors associated with preferential use of newer drugs were tested in univariate and multivariate analyses. Results: Newer antidepressants were included in the treatment regimens of 67.5% (N = 1282/1898) of study subjects. Prescription for newer antidepressants was significantly associated with younger age (z = -4.55, d.f. = 1888, P < 0.001), hospitalization [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.07, 1.64, P < 0.01] and treatment within psychiatric hospitals (OR 1.59, 95% CI 1.27, 2.00, P < 0.001). On multivariate analyses, treatment with newer antidepressants was independently associated with younger age (P < 0.001), country (P < 0.001) and treatment within private hospitals (P < 0.001), but not with sex or diagnosis of affective or anxiety disorders (all P > 0.1). Conclusion: Demographic factors and treatment settings appear to influence antidepressant choice more than clinical factors such as diagnosis.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume63
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1

Keywords

  • Antidepressant
  • Diagnosis
  • East Asia
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Sim, K., Lee, N. B., Chua, H. C., Mahendran, R., Fujii, S., Yang, S. Y., Chong, M. Y., Si, T., He, Y. L., Lee, M-S., Sung, K. M., Chung, E. K., Chan, Y. H., Shinfuku, N., Tan, C. H., Sartorius, N., & Baldessarini, R. J. (2007). Newer antidepressant drug use in East Asian psychiatric treatment settings: REAP (Research on East Asia Psychotropic Prescriptions) study. British Journal of Clinical Pharmacology, 63(4), 431-437. https://doi.org/10.1111/j.1365-2125.2006.02780.x