Ni-Au core-shell nanowires: Synthesis, microstructures, biofunctionalization, and the toxicological effects on pancreatic cancer cells

In Tak Jeon, Moon Kyu Cho, Jin Woo Cho, Boo Hyun An, Jun Hua Wu, Rosemarie Kringel, Daniel S. Choi, Young Keun Kim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The nickel (Ni)-gold (Au) core-shell nanowires (CSNWs) were synthesized by a combination of electrodeposition and electroless-plating methods. This template based, electroless-plating approach can control the size and shape of nanostructures by adjusting the experimental conditions. The X-ray diffraction, transmission electron microscopy (TEM), and TEM line-scanning and elemental mapping analyses were applied to investigate the formation and microstructure of the core-shell nanostructure. Also using a focused ion beam lift-out technique provides an important route to prove the inner microstructural details of the CSNWs. The optical characterization showed the surface plasmon absorption shifting with electroless-plating time, whereas the magnetic measurements revealed the shape anisotropy and soft ferromagnetic properties of the NWs. Using the strong interaction between biotin and streptavidin, streptavidin-fluorescent dyes were successfully conjugated on the biotinylated CSNWs. This was then analyzed for the surface plasmon resonance effect and Stokes' shifting via ultraviolet-visible and photoluminescence spectroscopy measurements and imaged by confocal scanning laser microscopy. Proliferating cancer cells (Panc-1) have been used to study the toxicological effects of both Ni-Au CSNWs and Ni NWs in a living cell system: the cellular responses to nanowire effects were observed. Ni-Au CSNWs appeared to be tolerated more by this cell line at the dose tested than Ni NWs.

Original languageEnglish
Pages (from-to)12089-12095
Number of pages7
JournalJournal of Materials Chemistry
Volume21
Issue number32
DOIs
Publication statusPublished - 2011 Aug 28

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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