NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu, Yi Zhang, Jun Li, Jusung An, Chonglu Li, Suya Bai, Amit Sharma, Ganzhen Deng, Jong Seung Kim, Yao Sun

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

Original languageEnglish
Article number120315
JournalBiomaterials
Volume259
DOIs
Publication statusPublished - 2020 Nov

Keywords

  • Aggregation-induced emission
  • Organic dye
  • Photodynamic therapy
  • Photothermal therapy
  • The second infrared channel

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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