NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu; Yi Zhang; Jun Li; Jusung An; Chonglu Li; Suya Bai; Amit Sharma; Ganzhen Deng; Jong Seung Kim; Yao Sun

doi:10.1016/j.biomaterials.2020.120315

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu, Yi Zhang, Jun Li, Jusung An, Chonglu Li, Suya Bai, Amit Sharma, Ganzhen Deng, Jong Seung Kim, Yao Sun

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

Original language	English
Article number	120315
Journal	Biomaterials
Volume	259
DOIs	https://doi.org/10.1016/j.biomaterials.2020.120315
Publication status	Published - 2020 Nov

Keywords

Aggregation-induced emission
Organic dye
Photodynamic therapy
Photothermal therapy
The second infrared channel

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2020.120315

Cite this

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title = "NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens",

abstract = "Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.",

keywords = "Aggregation-induced emission, Organic dye, Photodynamic therapy, Photothermal therapy, The second infrared channel",

author = "Yuling Xu and Yi Zhang and Jun Li and Jusung An and Chonglu Li and Suya Bai and Amit Sharma and Ganzhen Deng and Kim, {Jong Seung} and Yao Sun",

note = "Funding Information: This work was partially supported by grants from NSFC (21708012, 21806048, 31972744), NSFHP (2017CFB151), Wuhan Scientific and Technological Projects (2019020701011441), the Fundamental Research Funds for the Central Universities (No. 2662018QD009), CRI project (NO. 2018r1a3b1052702, J.S.K.) of the National Research Foundation of Korea. Funding Information: This work was partially supported by grants from NSFC ( 21708012 , 21806048 , 31972744 ), NSFHP ( 2017CFB151 ), Wuhan Scientific and Technological Projects ( 2019020701011441 ), the Fundamental Research Funds for the Central Universities (No. 2662018QD009 ), CRI project (NO. 2018r1a3b1052702 , J.S.K.) of the National Research Foundation of Korea . Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = nov,

doi = "10.1016/j.biomaterials.2020.120315",

language = "English",

volume = "259",

journal = "Biomaterials",

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publisher = "Elsevier BV",

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T1 - NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

AU - Xu, Yuling

AU - Zhang, Yi

AU - Li, Jun

AU - An, Jusung

AU - Li, Chonglu

AU - Bai, Suya

AU - Sharma, Amit

AU - Deng, Ganzhen

AU - Kim, Jong Seung

AU - Sun, Yao

N1 - Funding Information: This work was partially supported by grants from NSFC (21708012, 21806048, 31972744), NSFHP (2017CFB151), Wuhan Scientific and Technological Projects (2019020701011441), the Fundamental Research Funds for the Central Universities (No. 2662018QD009), CRI project (NO. 2018r1a3b1052702, J.S.K.) of the National Research Foundation of Korea. Funding Information: This work was partially supported by grants from NSFC ( 21708012 , 21806048 , 31972744 ), NSFHP ( 2017CFB151 ), Wuhan Scientific and Technological Projects ( 2019020701011441 ), the Fundamental Research Funds for the Central Universities (No. 2662018QD009 ), CRI project (NO. 2018r1a3b1052702 , J.S.K.) of the National Research Foundation of Korea . Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/11

Y1 - 2020/11

N2 - Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

AB - Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

KW - Aggregation-induced emission

KW - Organic dye

KW - Photodynamic therapy

KW - Photothermal therapy

KW - The second infrared channel

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JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

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ER -

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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