NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu; Yi Zhang; Jun Li; Jusung An; Chonglu Li; Suya Bai; Amit Sharma; Ganzhen Deng; Jong Seung Kim; Yao Sun

doi:10.1016/j.biomaterials.2020.120315

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Yuling Xu, Yi Zhang, Jun Li, Jusung An, Chonglu Li, Suya Bai, Amit Sharma, Ganzhen Deng, Jong Seung Kim, Yao Sun

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.

Original language	English
Article number	120315
Journal	Biomaterials
Volume	259
DOIs	https://doi.org/10.1016/j.biomaterials.2020.120315
Publication status	Published - 2020 Nov

Keywords

Aggregation-induced emission
Organic dye
Photodynamic therapy
Photothermal therapy
The second infrared channel

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens. / Xu, Yuling; Zhang, Yi; Li, Jun; An, Jusung; Li, Chonglu; Bai, Suya; Sharma, Amit; Deng, Ganzhen; Kim, Jong Seung; Sun, Yao.

In: Biomaterials, Vol. 259, 120315, 11.2020.

Research output: Contribution to journal › Article › peer-review

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title = "NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens",

abstract = "Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections.",

keywords = "Aggregation-induced emission, Organic dye, Photodynamic therapy, Photothermal therapy, The second infrared channel",

author = "Yuling Xu and Yi Zhang and Jun Li and Jusung An and Chonglu Li and Suya Bai and Amit Sharma and Ganzhen Deng and Kim, {Jong Seung} and Yao Sun",

note = "Funding Information: This work was partially supported by grants from NSFC ( 21708012 , 21806048 , 31972744 ), NSFHP ( 2017CFB151 ), Wuhan Scientific and Technological Projects ( 2019020701011441 ), the Fundamental Research Funds for the Central Universities (No. 2662018QD009 ), CRI project (NO. 2018r1a3b1052702 , J.S.K.) of the National Research Foundation of Korea . ",

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AU - An, Jusung

AU - Li, Chonglu

AU - Bai, Suya

AU - Sharma, Amit

AU - Deng, Ganzhen

AU - Kim, Jong Seung

AU - Sun, Yao

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KW - The second infrared channel

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