Nitrates administered by spray versus tablet: comparison of coronary vasodilation on CT angiography

Cherry Kim, Moin Ha, Wooil Kim, Sung Joon Park, Sung Ho Hwang, Hwan Seok Yong, Yu Whan Oh, Eun Young Kang, Jaehyung Cha, Seung Hwa Lee, Ki Yeol Lee

Research output: Contribution to journalArticle

Abstract

Objectives: To compare the coronary vasodilation effects of spray with those induced by tablet administration in coronary CT angiography (CCTA). Methods: A total of 2024 patients who underwent CCTA were identified for this retrospective study, including 828 patients with spray (spray group) and 1169 with tablets (tablet group). Of these, 93 patients underwent CCTA at least twice using both spray and tablets. The number of measurable segments and diameters of all 18 segments was measured. The number of measurable segments was compared between groups. Results: No statistically significant differences were evident between these two groups in terms of clinical characteristics. All coronary segments except the ramus intermedius (RI) and left posterior descending artery (L-PDA) were significantly larger in the spray group than in the tablet group (all p < 0.001). In peripheral and branch vessels, as well as in central and main coronary arteries, the diameters were significantly larger in the spray group than in the tablet group (all p < 0.001). Although not always statistically significant, all coronary segments tended to be more measurable on CCTA with spray than with tablet. In the subgroup that underwent CCTA twice using both spray and tablets, all coronary segments except the RI, obtuse marginal artery 2 (OM2), and L-PDA were significantly larger in the spray group than in the tablet group (all p < 0.05). Conclusion: Lingual isosorbide dinitrate (ISDN) spray was more efficacious than sublingual nitroglycerin (NTG) tablets in coronary vasodilation for CCTA. Therefore, lingual ISDN spray should be preferred over sublingual NTG tablets for CCTA. Key Points: • Lingual ISDN spray was more efficacious than sublingual NTG tablet for coronary vasodilation in coronary CT angiography, even in elderly patients. • The diameters of all coronary segments except RI and L-PDA were significantly larger, and there were significantly more coronary segments greater than 1.5 mm, except RI and L-PDA, in the spray group than in the tablet group in the whole study group. • Even in peripheral and branch vessels, the diameters of coronary arteries were significantly larger in the spray group than in the tablet group, and they were also larger in elderly patients.

Original languageEnglish
JournalEuropean Radiology
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Computed tomography angiography
  • Coronary vessels
  • Nitrates
  • Vasodilation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Nitrates administered by spray versus tablet: comparison of coronary vasodilation on CT angiography'. Together they form a unique fingerprint.

  • Cite this

    Kim, C., Ha, M., Kim, W., Park, S. J., Hwang, S. H., Yong, H. S., Oh, Y. W., Kang, E. Y., Cha, J., Lee, S. H., & Lee, K. Y. (Accepted/In press). Nitrates administered by spray versus tablet: comparison of coronary vasodilation on CT angiography. European Radiology. https://doi.org/10.1007/s00330-020-07104-0