NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: An autopsy case

Sang Cheul Oh, Chul Won Choi, Byung Soo Kim, Sang Won Shin, Yeul Hong Kim, Jin Soo Lee, Ja Kim Min, Woon Yong Jung, Han Kyeom Kim, Bum Woo Yeom, In Sun Kim, Jun Suk Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.

Original languageEnglish
Pages (from-to)480-483
Number of pages4
JournalInternational Journal of Hematology
Volume79
Issue number5
DOIs
Publication statusPublished - 2004 Jun 1

Fingerprint

Natural Killer T-Cells
T-Cell Lymphoma
Human Herpesvirus 4
Autopsy
HIV
Palatine Tonsil
Epstein-Barr Virus Nuclear Antigens
Granzymes
Aspergillosis
Opportunistic Infections
In Situ Hybridization
Radiotherapy
Lymphocytes
Staining and Labeling
Recurrence
Drug Therapy
Polymerase Chain Reaction
Messenger RNA
Neoplasms

Keywords

  • Epstein-Barr virus
  • Human immunodeficiency virus
  • NK/T-cell lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

@article{053bb9f2d65e4610ac8c6f3cba951d2a,
title = "NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: An autopsy case",
abstract = "Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.",
keywords = "Epstein-Barr virus, Human immunodeficiency virus, NK/T-cell lymphoma",
author = "Oh, {Sang Cheul} and Choi, {Chul Won} and Kim, {Byung Soo} and Shin, {Sang Won} and Kim, {Yeul Hong} and Lee, {Jin Soo} and Min, {Ja Kim} and Jung, {Woon Yong} and Kim, {Han Kyeom} and Yeom, {Bum Woo} and Kim, {In Sun} and Kim, {Jun Suk}",
year = "2004",
month = "6",
day = "1",
doi = "10.1532/IJH97.A10316",
language = "English",
volume = "79",
pages = "480--483",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus

T2 - An autopsy case

AU - Oh, Sang Cheul

AU - Choi, Chul Won

AU - Kim, Byung Soo

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Lee, Jin Soo

AU - Min, Ja Kim

AU - Jung, Woon Yong

AU - Kim, Han Kyeom

AU - Yeom, Bum Woo

AU - Kim, In Sun

AU - Kim, Jun Suk

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.

AB - Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.

KW - Epstein-Barr virus

KW - Human immunodeficiency virus

KW - NK/T-cell lymphoma

UR - http://www.scopus.com/inward/record.url?scp=3042658498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042658498&partnerID=8YFLogxK

U2 - 10.1532/IJH97.A10316

DO - 10.1532/IJH97.A10316

M3 - Article

C2 - 15239400

AN - SCOPUS:3042658498

VL - 79

SP - 480

EP - 483

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 5

ER -