Nm23-H 1/nucleoside diphosphate kinase as a key molecule in breast tumor angiogenesis

Bu Hyun Youn, Hag Dong Kim, Joon Kim

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Background: Neo-angiogenesis seems to be a critical feature of breast tumor growth, migration and metastasis. Inhibition of angiogenesis may provide information regarding treatment. Since angiogenesis is the result of complex processes, controlled by several angiogenic (pro- and/ or -anti) factors and their receptors, multiple ways to prevent or retrogress tumor-induced angiogenesis have been proposed. The clinically significant activity of bevacizumab and other antiangiogenic treatments have attracted a great deal of interest. Objective/methods: We discuss biological aspects of breast cancer angiogenesis and nucleoside diphosphate kinase (NDPK) as a key molecule in this process. Results/conclusions: In clinical and experimental trials, it was reported that NDPK is inversely related to breast cancer metastasis and angiogenesis. To inhibit the metastatic potential of cancer cells, Nm23-H1/NDP kinase appears to interact with many proteins involved in cellular signal transduction in angiogenesis and tumorigenesis, and therefore reduces the activation of the extracellular signal-regulated kinase (ERK)/MAPK in response to those signals.

Original languageEnglish
Pages (from-to)1419-1430
Number of pages12
JournalExpert Opinion on Therapeutic Targets
Volume12
Issue number11
DOIs
Publication statusPublished - 2008 Nov

Keywords

  • Angiogenesis
  • Breast cancer
  • Nm23-H1/NDP

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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