nm23-H1 protein expression and gene mutation in 150 patients with non-Hodgkin's lymphomas

Ju-Han Lee, Jin Cho Su, Xianglan Zhang, Zhenlong Zheng, Eung Seok Lee, Aeree Kim, Young Sik Kim, Yang Seok Chae, Insun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to compare with the clinicopathologic parameters. The expression of nm23-H1 protein was immunohistochemically examined in 150 cases of non-Hodgkin's lymphomas; 85 diffuse large B cell lymphomas (DLBCL), 18 marginal zone B cell lymphomas (MZL), 3 mantle cell lymphomas, 25 peripheral T cell lymphomas, not otherwise specified (TCLNOS), and 19 NK/T cell lymphomas (NK/T). Eighty-one cases (58 DLBCL, 6 MZL, 4 TCLNOS, and 13 NK/T) were studied for nm23-H1 gene mutation in exon 1 to 5. The high expression of nm23-H1 protein was associated with the high IPI score (p=0.019) and the low survival rate of the patients (p=0.0039). The gene mutation of nm23-H1 was detected in 10.3% of DLBCL and 30.7% of NK/T; but none in MZL and TCLNOS. The mutation was found in exon 1 in 5 cases, exon 2 in two cases, exon 4 in one case and both exon 1 and 2 in two cases. Our results suggest that the expression of nm23-H1 protein can be used as a poor prognostic marker in non-Hodgkin's lymphomas, and the mutational change of gene may operate in the lymphomagenesis.

Original languageEnglish
Pages (from-to)645-651
Number of pages7
JournalJournal of Korean Medical Science
Volume21
Issue number4
Publication statusPublished - 2006 Aug 15

    Fingerprint

Keywords

  • Lymphoma, Non-Hodgkin
  • Mutation
  • nm23-H1 Protein
  • Nucleoside diphosphate kinase A
  • Prognosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this