Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species

Suyeun Yu, Yeogil Jang, Donggi Paik, Eun Il Lee, Joong Jean Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells. However, Nmdmc physiological roles remain unveiled. We found that ubiquitous Nmdmc overexpression enhanced Drosophila lifespan and stress resistance. Interestingly, Nmdmc overexpression in the fat body was sufficient to increase lifespan and tolerance against oxidative stress. In addition, these conditions coincided with significant decreases in the levels of mitochondrial ROS and Hsp22 as well as with a significant increase in the copy number of mitochondrial DNA. These results suggest that Nmdmc overexpression should be beneficial for mitochondrial homeostasis and increasing lifespan.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume465
Issue number4
DOIs
Publication statusPublished - 2015 Aug 21

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Keywords

  • Drosophila
  • Longevity
  • Mitochondrial DNA
  • NMDMC
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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