No association between dopamine D3 receptor gene Ser9Gly polymorphism and tardive dyskinesia in schizophrenia

Heon-Jeong Lee, Seung G. Kang, Jung E. Choi, Young M. Park, Se W. Lim, Leen Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drug use. Ser9Gly polymorphism of the dopamine 3 receptor (DRD3) has been shown to affect dopamine binding affinity, and may contribute to the susceptibility of antipsychotic-induced TD. This study investigated the possible association between DRD3 gene variant and TD. Methods: We evaluated whether a DRD3 Ser9Gly polymorphism is associated with antipsychotic-induced TD in 209 Korean schizophrenia patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association between genotype and allele frequencies determined by the Ser9Gly polymorphism of DRD3 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Ser9Gly polymorphism of DRD3 does not contribute significantly to the risk of TD.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalClinical Psychopharmacology and Neuroscience
Volume6
Issue number2
Publication statusPublished - 2008 Aug 1

Fingerprint

Dopamine D3 Receptors
Schizophrenia
Antipsychotic Agents
Genes
Genotype
Dyskinesias
Dopamine Receptors
Tardive Dyskinesia
Gene Frequency
Sample Size
Dopamine

Keywords

  • Dopamine 3 receptor
  • Polymorphism
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

No association between dopamine D3 receptor gene Ser9Gly polymorphism and tardive dyskinesia in schizophrenia. / Lee, Heon-Jeong; Kang, Seung G.; Choi, Jung E.; Park, Young M.; Lim, Se W.; Kim, Leen.

In: Clinical Psychopharmacology and Neuroscience, Vol. 6, No. 2, 01.08.2008, p. 71-74.

Research output: Contribution to journalArticle

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AU - Lim, Se W.

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AB - Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drug use. Ser9Gly polymorphism of the dopamine 3 receptor (DRD3) has been shown to affect dopamine binding affinity, and may contribute to the susceptibility of antipsychotic-induced TD. This study investigated the possible association between DRD3 gene variant and TD. Methods: We evaluated whether a DRD3 Ser9Gly polymorphism is associated with antipsychotic-induced TD in 209 Korean schizophrenia patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association between genotype and allele frequencies determined by the Ser9Gly polymorphism of DRD3 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Ser9Gly polymorphism of DRD3 does not contribute significantly to the risk of TD.

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