No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia

Heon-Jeong Lee, Seung G. Kang, Jung E. Choi, Jong W. Paik, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In K. Jung, Leen Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotics. We evaluated whether a candidate functional polymorphism of the dopamine D4 receptor (DRD4) gene is associated with drug-induced TD in 209 Korean schizophrenic patients with TD (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. There was no significant association of the genotype and allele frequencies determined by the -521 C/T SNP of DRD4 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the 3 genotype groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that the DRD4 -521 C/T SNP does not contribute significantly to the risk for TD.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalNeuropsychobiology
Volume55
Issue number1
DOIs
Publication statusPublished - 2007 Jun 1

Fingerprint

Dopamine D4 Receptors
Schizophrenia
Genes
Antipsychotic Agents
Single Nucleotide Polymorphism
Drug-Induced Dyskinesia
Genotype
Dyskinesias
Gene Frequency
Sample Size
Tardive Dyskinesia

Keywords

  • Dopamine D4 receptor
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia. / Lee, Heon-Jeong; Kang, Seung G.; Choi, Jung E.; Paik, Jong W.; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min-Soo; Joe, Sook Haeng; Jung, In K.; Kim, Leen.

In: Neuropsychobiology, Vol. 55, No. 1, 01.06.2007, p. 47-51.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Kang, Seung G. ; Choi, Jung E. ; Paik, Jong W. ; Kim, Yong Ku ; Kim, Seung Hyun ; Lee, Min-Soo ; Joe, Sook Haeng ; Jung, In K. ; Kim, Leen. / No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia. In: Neuropsychobiology. 2007 ; Vol. 55, No. 1. pp. 47-51.
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