Abstract
Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Tree single nucleotide poly morphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. Tere were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
| Original language | English |
|---|---|
| Pages (from-to) | 191-194 |
| Number of pages | 4 |
| Journal | Psychiatry Investigation |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Jun 1 |
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Keywords
- PAWR
- Polymorphism
- Schizophrenia
- Tardive dyskinesia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
No association between PAWR gene polymorphisms and Tardive dyskinesia in schizophrenia patients. / Kim, Ii Soo; Yoon, Ho-Kyoung; Kang, Seung Gul; Park, Young Min; Kim, Yong Ku; Kim, Seung Hyun; Choi, Jung Eun; Kim, Leen; Lee, Heon-Jeong.
In: Psychiatry Investigation, Vol. 9, No. 2, 01.06.2012, p. 191-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No association between PAWR gene polymorphisms and Tardive dyskinesia in schizophrenia patients
AU - Kim, Ii Soo
AU - Yoon, Ho-Kyoung
AU - Kang, Seung Gul
AU - Park, Young Min
AU - Kim, Yong Ku
AU - Kim, Seung Hyun
AU - Choi, Jung Eun
AU - Kim, Leen
AU - Lee, Heon-Jeong
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Tree single nucleotide poly morphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. Tere were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
AB - Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Tree single nucleotide poly morphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. Tere were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
KW - PAWR
KW - Polymorphism
KW - Schizophrenia
KW - Tardive dyskinesia
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UR - http://www.scopus.com/inward/citedby.url?scp=84863495501&partnerID=8YFLogxK
U2 - 10.4306/pi.2012.9.2.191
DO - 10.4306/pi.2012.9.2.191
M3 - Article
C2 - 22707972
AN - SCOPUS:84863495501
VL - 9
SP - 191
EP - 194
JO - Psychiatry Investigation
JF - Psychiatry Investigation
SN - 1738-3684
IS - 2
ER -