No association between PAWR gene polymorphisms and Tardive dyskinesia in schizophrenia patients

Ii Soo Kim, Ho Kyoung Yoon, Seung Gul Kang, Young Min Park, Yong Ku Kim, Seung Hyun Kim, Jung Eun Choi, Leen Kim, Heon Jeong Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Tree single nucleotide poly morphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. Tere were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalPsychiatry Investigation
Volume9
Issue number2
DOIs
Publication statusPublished - 2012 Jun

Keywords

  • PAWR
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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