Abstract
Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Tree single nucleotide poly morphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. Tere were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
Original language | English |
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Pages (from-to) | 191-194 |
Number of pages | 4 |
Journal | Psychiatry Investigation |
Volume | 9 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2012 Jun |
Keywords
- PAWR
- Polymorphism
- Schizophrenia
- Tardive dyskinesia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry