No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects

Heon-Jeong Lee, Se Won Lim, Jong Woo Paik, Min-Soo Lee, Leen Kim

Research output: Contribution to journalArticle


Smoking behavior has been regarded as being influenced by genetic factors. The aim of this study was to investigate if the -1438 A/G polymorphism of the Serotonin 2A receptor (5-HTR2A) gene is related to nicotine dependence, since this receptor modulates the mesolimbic dopamine system which is associated with drug addiction. The Fagerstrom test for nicotine dependence was used to determine the smoking behavior. A genotyping based PCR method was performed in 72 smokers and 134 nonsmokers. The -1438 A/G SNP showed no significant difference between the smokers and non-smokers in either the genotype or the allele frequency (p=0.84, p=0.85). These findings suggest that the -1438 A/G polymorphism of 5-HTR2A does not play a major role in the susceptibility to nicotine dependence in the Korean population.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
JournalClinical Psychopharmacology and Neuroscience
Issue number1
Publication statusPublished - 2005 Dec 1



  • 5-HTR2A
  • Polymorphism
  • Serotonin
  • Smoking

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology (medical)
  • Psychiatry and Mental health

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