No association between serotonin receptor 2C -759C/T polymorphism and weight change or treatment response to mirtazapine in Korean depressive patients

Hwa Young Lee, Chae Keun Oh, Byung-Joo Ham, Hun Soo Chang, Jong Woo Paik, Eun Soo Won, Sang Woo Hahn, Se Hoon Shim, Young Joon Kwon, Hee Yeon Jung, Min-Soo Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to be associated with antidepressant action and weight gain. We sought to determine whether the 5-HTR 2C receptor -759C/T polymorphism was associated with weight gain and treatment response to mirtazapine in major depressive disorder (MDD) patients. Methods The 5-HT 2C receptor -759C/T polymorphism was analyzed in 323 MDD patients. All patients were evaluated using the 21- item Hamilton Depression Rating Scale at the beginning of the study and at 1, 2, 4, and 8 weeks of mirtazapine treatment. Results There was no significant difference in the 5-HT 2C receptor -759C/T genotype distribution between responder and non-responder groups. The 5-HT 2C receptor -759C/T polymorphism was not associated with weight change over time after mirtazapine administration. Conclusion The 5-HT 2C receptor -759C/T polymorphism does not appear to be a predictor of treatment response to mirtazapine. This polymorphism was not associated with weight change after 8 weeks of mirtazapine treatment. Further investigation on other polymorphisms of the 5-HT 2C gene is required to determine whether the 5-HT 2C gene influences treatment response and weight change after mirtazapine administration in patients with major depressive disorder.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalPsychiatry Investigation
Volume10
Issue number2
DOIs
Publication statusPublished - 2013 Jun 1

Keywords

  • Major depressive disorder
  • Mirtazapine
  • Polymorphism
  • Serotonin 2C receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Lee, H. Y., Oh, C. K., Ham, B-J., Chang, H. S., Paik, J. W., Won, E. S., Hahn, S. W., Shim, S. H., Kwon, Y. J., Jung, H. Y., & Lee, M-S. (2013). No association between serotonin receptor 2C -759C/T polymorphism and weight change or treatment response to mirtazapine in Korean depressive patients. Psychiatry Investigation, 10(2), 190-195. https://doi.org/10.4306/pi.2013.10.2.190