No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

Seung Gul Kang, Jung Eun Choi, Hyonggin An, Se Won Lim, Heon-Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ2 = 2.37, p = 0.306) and alleles (χ2 = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown

Original languageEnglish
Pages (from-to)1545-1548
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number6
DOIs
Publication statusPublished - 2008 Aug 1

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Brain-Derived Neurotrophic Factor
Antipsychotic Agents
Single Nucleotide Polymorphism
Genes
Crowns
Schizophrenia
Alleles
Genotype
Tardive Dyskinesia

Keywords

  • Brain-derived neurotrophic factor
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients. / Kang, Seung Gul; Choi, Jung Eun; An, Hyonggin; Lim, Se Won; Lee, Heon-Jeong; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Cho, Sung Nam; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Kim, Leen.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 6, 01.08.2008, p. 1545-1548.

Research output: Contribution to journalArticle

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AU - An, Hyonggin

AU - Lim, Se Won

AU - Lee, Heon-Jeong

AU - Han, Changsu

AU - Kim, Yong Ku

AU - Kim, Seung Hyun

AU - Cho, Sung Nam

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AU - Joe, Sook Haeng

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AU - Kim, Leen

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AB - Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ2 = 2.37, p = 0.306) and alleles (χ2 = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown

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