No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

Seung Gul Kang, Jung Eun Choi, Hyonggin An, Se Won Lim, Heon Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ2 = 2.37, p = 0.306) and alleles (χ2 = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown

Original languageEnglish
Pages (from-to)1545-1548
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number6
DOIs
Publication statusPublished - 2008 Aug 1

Keywords

  • Brain-derived neurotrophic factor
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients'. Together they form a unique fingerprint.

Cite this