No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population

Young Ho Lee; Seong Jai Choi; Jong Dae Ji; Gwan Gyu Song

doi:10.1080/030097402760375142

No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population

Young Ho Lee, Seong Jai Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+49) and promoter(-318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+49) and promoter(-318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+49) and promoter(-318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class (≥3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.

Original language	English
Pages (from-to)	266-270
Number of pages	5
Journal	Scandinavian Journal of Rheumatology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1080/030097402760375142
Publication status	Published - 2002

Keywords

CTLA-4 polymorphisms
Rheumatoid arthritis

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

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10.1080/030097402760375142

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title = "No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population",

abstract = "The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+49) and promoter(-318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+49) and promoter(-318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+49) and promoter(-318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class (≥3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.",

keywords = "CTLA-4 polymorphisms, Rheumatoid arthritis",

author = "Lee, {Young Ho} and Choi, {Seong Jai} and Ji, {Jong Dae} and Song, {Gwan Gyu}",

note = "Funding Information: This work was supported baygntrfamrtoehKaHoalhrtee 21 R&D Project, Miintrsy of Halhte&Wlrf(ae10-P-J3-PG6 01GN09-003).",

year = "2002",

doi = "10.1080/030097402760375142",

language = "English",

volume = "31",

pages = "266--270",

journal = "Scandinavian Journal of Rheumatology",

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T1 - No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population

AU - Lee, Young Ho

AU - Choi, Seong Jai

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

N1 - Funding Information: This work was supported baygntrfamrtoehKaHoalhrtee 21 R&D Project, Miintrsy of Halhte&Wlrf(ae10-P-J3-PG6 01GN09-003).

PY - 2002

Y1 - 2002

N2 - The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+49) and promoter(-318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+49) and promoter(-318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+49) and promoter(-318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class (≥3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.

AB - The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+49) and promoter(-318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+49) and promoter(-318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+49) and promoter(-318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class (≥3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.

KW - CTLA-4 polymorphisms

KW - Rheumatoid arthritis

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U2 - 10.1080/030097402760375142

DO - 10.1080/030097402760375142

M3 - Article

C2 - 12455815

AN - SCOPUS:0036035619

VL - 31

SP - 266

EP - 270

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 5

ER -

No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population

Abstract

Keywords

ASJC Scopus subject areas

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