No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population

Young Ho Lee, Seong Jai Choi, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+49) and promoter(-318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+49) and promoter(-318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+49) and promoter(-318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class (≥3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.

    Original languageEnglish
    Pages (from-to)266-270
    Number of pages5
    JournalScandinavian Journal of Rheumatology
    Volume31
    Issue number5
    DOIs
    Publication statusPublished - 2002

    Keywords

    • CTLA-4 polymorphisms
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Rheumatology
    • Immunology

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