Abstract
After a single bout of prolonged strenuous exercise, inflammatory and muscle damage markers increase. The present study investigated whether vitamin E supplementation can attenuate inflammatory (C-reactive protein (CRP) and interleukin-6 (IL-6)) and muscle damage (creatine kinase (CK) and lactate dehydrogenese (LDH)) markers after prolonged repeated bouts of cycling in healthy young men. Eight young males (aged 21-30 y) were received both vitamin E supplement (300 mg/day) and placebo (control) for 14 days separated by at least an interval of 1 month in a randomised, counterbalanced design. On day 12 of both trials, subjects cycled at 80% of maximal heart rate in two, 90-min bouts (150 min rest between each). Blood samples were collected on days 1 (baseline), 12 (pre- and post-exercise 1 and pre- and post-exercise 2), 13, 14, and 15. After 14 days of supplementation, serum α-tocopherol concentrations increased in the vitamin E trial (P<0.0005) but not the placebo trial. Serum CRP concentrations did not differ between trials and did not significantly change over the observation period in both trials. Serum IL-6, CK, and LDH concentrations increased (P≤0.024) in response to repeated bouts of exercise in both trials but did not differ between trials. The study demonstrates that short-term vitamin E supplementation appears to have no effect on attenuating markers of inflammatory and muscle damage in response to repeated bouts of prolonged exercise in healthy young men.
| Original language | English |
|---|---|
| Pages (from-to) | 383-392 |
| Number of pages | 10 |
| Journal | Japanese Journal of Physical Fitness and Sports Medicine |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2008 Jan 1 |
| Externally published | Yes |
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Keywords
- Inflammation
- Muscle damage
- Repeated exercise
- Vitamin E
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
No effects of short-term vitamin E supplementation on inflammatory and muscle damage markers after repeated bouts of prolonged exercise in healthy young men. / Miyashita, Masashi; Park, Jonghoon.
In: Japanese Journal of Physical Fitness and Sports Medicine, Vol. 57, No. 3, 01.01.2008, p. 383-392.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No effects of short-term vitamin E supplementation on inflammatory and muscle damage markers after repeated bouts of prolonged exercise in healthy young men
AU - Miyashita, Masashi
AU - Park, Jonghoon
PY - 2008/1/1
Y1 - 2008/1/1
N2 - After a single bout of prolonged strenuous exercise, inflammatory and muscle damage markers increase. The present study investigated whether vitamin E supplementation can attenuate inflammatory (C-reactive protein (CRP) and interleukin-6 (IL-6)) and muscle damage (creatine kinase (CK) and lactate dehydrogenese (LDH)) markers after prolonged repeated bouts of cycling in healthy young men. Eight young males (aged 21-30 y) were received both vitamin E supplement (300 mg/day) and placebo (control) for 14 days separated by at least an interval of 1 month in a randomised, counterbalanced design. On day 12 of both trials, subjects cycled at 80% of maximal heart rate in two, 90-min bouts (150 min rest between each). Blood samples were collected on days 1 (baseline), 12 (pre- and post-exercise 1 and pre- and post-exercise 2), 13, 14, and 15. After 14 days of supplementation, serum α-tocopherol concentrations increased in the vitamin E trial (P<0.0005) but not the placebo trial. Serum CRP concentrations did not differ between trials and did not significantly change over the observation period in both trials. Serum IL-6, CK, and LDH concentrations increased (P≤0.024) in response to repeated bouts of exercise in both trials but did not differ between trials. The study demonstrates that short-term vitamin E supplementation appears to have no effect on attenuating markers of inflammatory and muscle damage in response to repeated bouts of prolonged exercise in healthy young men.
AB - After a single bout of prolonged strenuous exercise, inflammatory and muscle damage markers increase. The present study investigated whether vitamin E supplementation can attenuate inflammatory (C-reactive protein (CRP) and interleukin-6 (IL-6)) and muscle damage (creatine kinase (CK) and lactate dehydrogenese (LDH)) markers after prolonged repeated bouts of cycling in healthy young men. Eight young males (aged 21-30 y) were received both vitamin E supplement (300 mg/day) and placebo (control) for 14 days separated by at least an interval of 1 month in a randomised, counterbalanced design. On day 12 of both trials, subjects cycled at 80% of maximal heart rate in two, 90-min bouts (150 min rest between each). Blood samples were collected on days 1 (baseline), 12 (pre- and post-exercise 1 and pre- and post-exercise 2), 13, 14, and 15. After 14 days of supplementation, serum α-tocopherol concentrations increased in the vitamin E trial (P<0.0005) but not the placebo trial. Serum CRP concentrations did not differ between trials and did not significantly change over the observation period in both trials. Serum IL-6, CK, and LDH concentrations increased (P≤0.024) in response to repeated bouts of exercise in both trials but did not differ between trials. The study demonstrates that short-term vitamin E supplementation appears to have no effect on attenuating markers of inflammatory and muscle damage in response to repeated bouts of prolonged exercise in healthy young men.
KW - Inflammation
KW - Muscle damage
KW - Repeated exercise
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=47649130329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47649130329&partnerID=8YFLogxK
U2 - 10.7600/jspfsm.57.383
DO - 10.7600/jspfsm.57.383
M3 - Article
AN - SCOPUS:47649130329
VL - 57
SP - 383
EP - 392
JO - Japanese Journal of Physical Fitness and Sports Medicine
JF - Japanese Journal of Physical Fitness and Sports Medicine
SN - 0039-906X
IS - 3
ER -