No evidence for an association between dopamine D2 receptor polymorphisms and tardive dyskinesia in Korean schizophrenia patients

Young Min Park, Seung Gul Kang, Jung Eun Choi, Yong Ku Kim, Seung Hyun Kim, Ji Young Park, Leen Kim, Heon-Jeong Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic- induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (- 41Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalPsychiatry Investigation
Volume8
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Dopamine D2 Receptors
Schizophrenia
Antipsychotic Agents
Haplotypes
Dyskinesias
Tardive Dyskinesia
Genes
Single Nucleotide Polymorphism

Keywords

  • Association
  • Dopamine receptor
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

No evidence for an association between dopamine D2 receptor polymorphisms and tardive dyskinesia in Korean schizophrenia patients. / Park, Young Min; Kang, Seung Gul; Choi, Jung Eun; Kim, Yong Ku; Kim, Seung Hyun; Park, Ji Young; Kim, Leen; Lee, Heon-Jeong.

In: Psychiatry Investigation, Vol. 8, No. 1, 01.03.2011, p. 49-54.

Research output: Contribution to journalArticle

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abstract = "Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic- induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (- 41Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7{\%} vs. 8.5{\%}, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.",
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N2 - Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic- induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (- 41Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.

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