No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

Heon-Jeong Lee, Seung Gul Kang, Jong Woo Paik, Moon-Soo Lee, Bang Hyun Cho, Young Min Park, Won Kim, Jung Eun Choi, In Kwa Jung, Leen Kim, Min-Soo Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalHuman Psychopharmacology
Volume22
Issue number8
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Protein Subunits
GTP-Binding Proteins
Schizophrenia
Genes
Antipsychotic Agents
Drug-Induced Dyskinesia
Tardive Dyskinesia
Gene Frequency
Sample Size
Single Nucleotide Polymorphism
Genotype

Keywords

  • G protein
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Psychology(all)
  • Neuroscience(all)
  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Neurology
  • Clinical Neurology

Cite this

No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia. / Lee, Heon-Jeong; Kang, Seung Gul; Paik, Jong Woo; Lee, Moon-Soo; Cho, Bang Hyun; Park, Young Min; Kim, Won; Choi, Jung Eun; Jung, In Kwa; Kim, Leen; Lee, Min-Soo.

In: Human Psychopharmacology, Vol. 22, No. 8, 01.12.2007, p. 501-504.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Kang, Seung Gul ; Paik, Jong Woo ; Lee, Moon-Soo ; Cho, Bang Hyun ; Park, Young Min ; Kim, Won ; Choi, Jung Eun ; Jung, In Kwa ; Kim, Leen ; Lee, Min-Soo. / No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia. In: Human Psychopharmacology. 2007 ; Vol. 22, No. 8. pp. 501-504.
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AU - Cho, Bang Hyun

AU - Park, Young Min

AU - Kim, Won

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AB - Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

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