No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

Heon-Jeong Lee, Seung Gul Kang, Jong Woo Paik, Moon-Soo Lee, Bang Hyun Cho, Young Min Park, Won Kim, Jung Eun Choi, In Kwa Jung, Leen Kim, Min-Soo Lee

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Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalHuman Psychopharmacology
Issue number8
Publication statusPublished - 2007 Dec 1



  • G protein
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Psychology(all)
  • Neuroscience(all)
  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Neurology
  • Clinical Neurology

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