No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

Heon Jeong Lee; Seung Gul Kang; Jong Woo Paik; Moon Soo Lee; Bang Hyun Cho; Young Min Park; Won Kim; Jung Eun Choi; In Kwa Jung; Leen Kim; Min Soo Lee

doi:10.1002/hup.875

No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

Heon Jeong Lee, Seung Gul Kang, Jong Woo Paik, Moon Soo Lee, Bang Hyun Cho, Young Min Park, Won Kim, Jung Eun Choi, In Kwa Jung, Leen Kim, Min Soo Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

Original language	English
Pages (from-to)	501-504
Number of pages	4
Journal	Human Psychopharmacology
Volume	22
Issue number	8
DOIs	https://doi.org/10.1002/hup.875
Publication status	Published - 2007 Dec

Keywords

G protein
Polymorphism
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hup.875

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title = "No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia",

abstract = "Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.",

keywords = "G protein, Polymorphism, Schizophrenia, Tardive dyskinesia",

author = "Lee, {Heon Jeong} and Kang, {Seung Gul} and Paik, {Jong Woo} and Lee, {Moon Soo} and Cho, {Bang Hyun} and Park, {Young Min} and Won Kim and Choi, {Jung Eun} and Jung, {In Kwa} and Leen Kim and Lee, {Min Soo}",

year = "2007",

month = dec,

doi = "10.1002/hup.875",

language = "English",

volume = "22",

pages = "501--504",

journal = "Human Psychopharmacology",

issn = "0885-6222",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

AU - Lee, Heon Jeong

AU - Kang, Seung Gul

AU - Paik, Jong Woo

AU - Lee, Moon Soo

AU - Cho, Bang Hyun

AU - Park, Young Min

AU - Kim, Won

AU - Choi, Jung Eun

AU - Jung, In Kwa

AU - Kim, Leen

AU - Lee, Min Soo

PY - 2007/12

Y1 - 2007/12

N2 - Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

AB - Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein β3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients. Methods: We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables. Results: The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05). Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

KW - G protein

KW - Polymorphism

KW - Schizophrenia

KW - Tardive dyskinesia

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No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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