No evidence for association between tyrosine hydroxylase gene Val81Met polymorphism and susceptibility to tardive dyskinesia in schizophrenia

Heon-Jeong Lee, Seung G. Kang, Jung E. Choi, Young M. Park, Se W. Lim, Kyu Rhee Min, Seung Hyun Kim, Leen Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. Methods: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalPsychiatry Investigation
Volume6
Issue number2
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Tyrosine 3-Monooxygenase
Schizophrenia
Genes
Dopamine
Genotype
Dyskinesias
Enzymes
Gene Frequency
Sample Size
Antipsychotic Agents
Tardive Dyskinesia
Polymerase Chain Reaction

Keywords

  • Polymorphism
  • Tardive dyskinesia
  • Tyrosine hydoxylase

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

No evidence for association between tyrosine hydroxylase gene Val81Met polymorphism and susceptibility to tardive dyskinesia in schizophrenia. / Lee, Heon-Jeong; Kang, Seung G.; Choi, Jung E.; Park, Young M.; Lim, Se W.; Min, Kyu Rhee; Kim, Seung Hyun; Kim, Leen.

In: Psychiatry Investigation, Vol. 6, No. 2, 01.06.2009, p. 108-111.

Research output: Contribution to journalArticle

@article{aaeaf1040d324bf881b5f6c52b5d10c4,
title = "No evidence for association between tyrosine hydroxylase gene Val81Met polymorphism and susceptibility to tardive dyskinesia in schizophrenia",
abstract = "Objective: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. Methods: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.",
keywords = "Polymorphism, Tardive dyskinesia, Tyrosine hydoxylase",
author = "Heon-Jeong Lee and Kang, {Seung G.} and Choi, {Jung E.} and Park, {Young M.} and Lim, {Se W.} and Min, {Kyu Rhee} and Kim, {Seung Hyun} and Leen Kim",
year = "2009",
month = "6",
day = "1",
doi = "10.4306/pi.2009.6.2.108",
language = "English",
volume = "6",
pages = "108--111",
journal = "Psychiatry Investigation",
issn = "1738-3684",
publisher = "Korean Neuropsychiatric Association",
number = "2",

}

TY - JOUR

T1 - No evidence for association between tyrosine hydroxylase gene Val81Met polymorphism and susceptibility to tardive dyskinesia in schizophrenia

AU - Lee, Heon-Jeong

AU - Kang, Seung G.

AU - Choi, Jung E.

AU - Park, Young M.

AU - Lim, Se W.

AU - Min, Kyu Rhee

AU - Kim, Seung Hyun

AU - Kim, Leen

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Objective: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. Methods: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.

AB - Objective: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. Methods: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.

KW - Polymorphism

KW - Tardive dyskinesia

KW - Tyrosine hydoxylase

UR - http://www.scopus.com/inward/record.url?scp=67651174668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651174668&partnerID=8YFLogxK

U2 - 10.4306/pi.2009.6.2.108

DO - 10.4306/pi.2009.6.2.108

M3 - Article

VL - 6

SP - 108

EP - 111

JO - Psychiatry Investigation

JF - Psychiatry Investigation

SN - 1738-3684

IS - 2

ER -