Abstract
Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.
| Original language | English |
|---|---|
| Pages (from-to) | 449-457 |
| Number of pages | 9 |
| Journal | Bioorganic Chemistry |
| Volume | 76 |
| DOIs | |
| Publication status | Published - 2018 Feb 1 |
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Keywords
- Blumea balsamifera
- Diterpenoids
- Molecular docking
- NO inhibitory activities
- Sesquiterpenoids
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Drug Discovery
- Organic Chemistry
Cite this
NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera. / Ma, Jun; Ren, Quanhui; Dong, Bangjian; Shi, Zhaoyu; Zhang, Jie; Jin, Da Qing; Xu, Jing; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang.
In: Bioorganic Chemistry, Vol. 76, 01.02.2018, p. 449-457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera
AU - Ma, Jun
AU - Ren, Quanhui
AU - Dong, Bangjian
AU - Shi, Zhaoyu
AU - Zhang, Jie
AU - Jin, Da Qing
AU - Xu, Jing
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Guo, Yuanqiang
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.
AB - Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.
KW - Blumea balsamifera
KW - Diterpenoids
KW - Molecular docking
KW - NO inhibitory activities
KW - Sesquiterpenoids
UR - http://www.scopus.com/inward/record.url?scp=85038834506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038834506&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2017.12.008
DO - 10.1016/j.bioorg.2017.12.008
M3 - Article
C2 - 29275263
AN - SCOPUS:85038834506
VL - 76
SP - 449
EP - 457
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
ER -