NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Jun Ma; Quanhui Ren; Bangjian Dong; Zhaoyu Shi; Jie Zhang; Da Qing Jin; Jing Xu; Yasushi Ohizumi; Dongho Lee; Yuanqiang Guo

doi:10.1016/j.bioorg.2017.12.008

NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Jun Ma, Quanhui Ren, Bangjian Dong, Zhaoyu Shi, Jie Zhang, Da Qing Jin, Jing Xu, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.

Original language	English
Pages (from-to)	449-457
Number of pages	9
Journal	Bioorganic Chemistry
Volume	76
DOIs	https://doi.org/10.1016/j.bioorg.2017.12.008
Publication status	Published - 2018 Feb

Keywords

Blumea balsamifera
Diterpenoids
Molecular docking
NO inhibitory activities
Sesquiterpenoids

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2017.12.008

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title = "NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera",

abstract = "Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.",

keywords = "Blumea balsamifera, Diterpenoids, Molecular docking, NO inhibitory activities, Sesquiterpenoids",

author = "Jun Ma and Quanhui Ren and Bangjian Dong and Zhaoyu Shi and Jie Zhang and Jin, {Da Qing} and Jing Xu and Yasushi Ohizumi and Dongho Lee and Yuanqiang Guo",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 21372125 , 21642016 , and U1703107 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Fundamental Research Funds for the Central Universities, Hundred Young Academic Leaders Program of Nankai University , and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = feb,

doi = "10.1016/j.bioorg.2017.12.008",

language = "English",

volume = "76",

pages = "449--457",

journal = "Bioorganic Chemistry",

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AU - Ma, Jun

AU - Ren, Quanhui

AU - Dong, Bangjian

AU - Shi, Zhaoyu

AU - Zhang, Jie

AU - Jin, Da Qing

AU - Xu, Jing

AU - Ohizumi, Yasushi

AU - Lee, Dongho

AU - Guo, Yuanqiang

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 21372125 , 21642016 , and U1703107 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Fundamental Research Funds for the Central Universities, Hundred Young Academic Leaders Program of Nankai University , and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ). Publisher Copyright: © 2017 Elsevier Inc.

PY - 2018/2

Y1 - 2018/2

N2 - Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.

AB - Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.

KW - Blumea balsamifera

KW - Diterpenoids

KW - Molecular docking

KW - NO inhibitory activities

KW - Sesquiterpenoids

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DO - 10.1016/j.bioorg.2017.12.008

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AN - SCOPUS:85038834506

VL - 76

SP - 449

EP - 457

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

SN - 0045-2068

ER -

NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Abstract

Keywords

ASJC Scopus subject areas

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