NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Jun Ma, Quanhui Ren, Bangjian Dong, Zhaoyu Shi, Jie Zhang, Da Qing Jin, Jing Xu, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalBioorganic Chemistry
Volume76
DOIs
Publication statusPublished - 2018 Feb

Keywords

  • Blumea balsamifera
  • Diterpenoids
  • Molecular docking
  • NO inhibitory activities
  • Sesquiterpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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