NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo

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4 Citations (Scopus)

Abstract

Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

Original languageEnglish
Article number103237
JournalBioorganic Chemistry
Volume92
DOIs
Publication statusPublished - 2019 Nov

Keywords

  • Diterpenoids
  • Euphorbia antiquorum
  • Inflammation
  • Molecular docking
  • NO inhibitory effects

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    An, L., Liang, Y., Yang, X., Wang, H., Zhang, J., Tuerhong, M., Li, D., Wang, C., Lee, D., Xu, J., Shuai, L., Jin, J., & Guo, Y. (2019). NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum. Bioorganic Chemistry, 92, [103237]. https://doi.org/10.1016/j.bioorg.2019.103237