TY - JOUR
T1 - NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum
AU - An, Lijun
AU - Liang, Yue
AU - Yang, Xueyuan
AU - Wang, Huimei
AU - Zhang, Jie
AU - Tuerhong, Muhetaer
AU - Li, Dihua
AU - Wang, Chunyan
AU - Lee, Dongho
AU - Xu, Jing
AU - Shuai, Ling
AU - Jin, Jin
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), the Fundamental Research Funds for the Central Universities, Nankai University (Nos. 63191142 and 63191731 ), and the Natural Science Foundation of Tianjin (No. 16JCQNJC13500 ).
Publisher Copyright:
© 2019 Elsevier Inc.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
AB - Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
KW - Diterpenoids
KW - Euphorbia antiquorum
KW - Inflammation
KW - Molecular docking
KW - NO inhibitory effects
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U2 - 10.1016/j.bioorg.2019.103237
DO - 10.1016/j.bioorg.2019.103237
M3 - Article
C2 - 31536954
AN - SCOPUS:85072252605
VL - 92
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
M1 - 103237
ER -