NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An; Yue Liang; Xueyuan Yang; Huimei Wang; Jie Zhang; Muhetaer Tuerhong; Dihua Li; Chunyan Wang; Dongho Lee; Jing Xu; Ling Shuai; Jin Jin; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.103237

NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC₅₀ values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

Original language	English
Article number	103237
Journal	Bioorganic Chemistry
Volume	92
DOIs	https://doi.org/10.1016/j.bioorg.2019.103237
Publication status	Published - 2019 Nov

Keywords

Diterpenoids
Euphorbia antiquorum
Inflammation
Molecular docking
NO inhibitory effects

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.bioorg.2019.103237

Fingerprint Dive into the research topics of 'NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum'. Together they form a unique fingerprint.

Cite this

An, L., Liang, Y., Yang, X., Wang, H., Zhang, J., Tuerhong, M., Li, D., Wang, C., Lee, D., Xu, J., Shuai, L., Jin, J., & Guo, Y. (2019). NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum. Bioorganic Chemistry, 92, [103237]. https://doi.org/10.1016/j.bioorg.2019.103237

@article{f9afacb3414e4b9fb2fbecc10666628c,

title = "NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum",

abstract = "Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.",

keywords = "Diterpenoids, Euphorbia antiquorum, Inflammation, Molecular docking, NO inhibitory effects",

author = "Lijun An and Yue Liang and Xueyuan Yang and Huimei Wang and Jie Zhang and Muhetaer Tuerhong and Dihua Li and Chunyan Wang and Dongho Lee and Jing Xu and Ling Shuai and Jin Jin and Yuanqiang Guo",

year = "2019",

month = nov,

doi = "10.1016/j.bioorg.2019.103237",

language = "English",

volume = "92",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

AU - An, Lijun

AU - Liang, Yue

AU - Yang, Xueyuan

AU - Wang, Huimei

AU - Zhang, Jie

AU - Tuerhong, Muhetaer

AU - Li, Dihua

AU - Wang, Chunyan

AU - Lee, Dongho

AU - Xu, Jing

AU - Shuai, Ling

AU - Jin, Jin

AU - Guo, Yuanqiang

PY - 2019/11

Y1 - 2019/11

N2 - Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

AB - Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

KW - Diterpenoids

KW - Euphorbia antiquorum

KW - Inflammation

KW - Molecular docking

KW - NO inhibitory effects

UR - http://www.scopus.com/inward/record.url?scp=85072252605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072252605&partnerID=8YFLogxK

U2 - 10.1016/j.bioorg.2019.103237

DO - 10.1016/j.bioorg.2019.103237

M3 - Article

C2 - 31536954

AN - SCOPUS:85072252605

VL - 92

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

SN - 0045-2068

M1 - 103237

ER -