@article{f9afacb3414e4b9fb2fbecc10666628c,
title = "NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum",
abstract = "Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.",
keywords = "Diterpenoids, Euphorbia antiquorum, Inflammation, Molecular docking, NO inhibitory effects",
author = "Lijun An and Yue Liang and Xueyuan Yang and Huimei Wang and Jie Zhang and Muhetaer Tuerhong and Dihua Li and Chunyan Wang and Dongho Lee and Jing Xu and Ling Shuai and Jin Jin and Yuanqiang Guo",
note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), the Fundamental Research Funds for the Central Universities, Nankai University (Nos. 63191142 and 63191731 ), and the Natural Science Foundation of Tianjin (No. 16JCQNJC13500 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = nov,
doi = "10.1016/j.bioorg.2019.103237",
language = "English",
volume = "92",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}