NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An; Yue Liang; Xueyuan Yang; Huimei Wang; Jie Zhang; Muhetaer Tuerhong; Dihua Li; Chunyan Wang; Dongho Lee; Jing Xu; Ling Shuai; Jin Jin; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.103237

NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC₅₀ values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

Original language	English
Article number	103237
Journal	Bioorganic Chemistry
Volume	92
DOIs	https://doi.org/10.1016/j.bioorg.2019.103237
Publication status	Published - 2019 Nov 1

Keywords

Diterpenoids
Euphorbia antiquorum
Inflammation
Molecular docking
NO inhibitory effects

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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An, L., Liang, Y., Yang, X., Wang, H., Zhang, J., Tuerhong, M., Li, D., Wang, C., Lee, D., Xu, J., Shuai, L., Jin, J., & Guo, Y. (2019). NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum. Bioorganic Chemistry, 92, [103237]. https://doi.org/10.1016/j.bioorg.2019.103237

NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum. / An, Lijun; Liang, Yue; Yang, Xueyuan; Wang, Huimei; Zhang, Jie; Tuerhong, Muhetaer; Li, Dihua; Wang, Chunyan; Lee, Dongho; Xu, Jing; Shuai, Ling; Jin, Jin; Guo, Yuanqiang.

In: Bioorganic Chemistry, Vol. 92, 103237, 01.11.2019.

Research output: Contribution to journal › Article

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AU - Tuerhong, Muhetaer

AU - Li, Dihua

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AU - Lee, Dongho

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AU - Shuai, Ling

AU - Jin, Jin

AU - Guo, Yuanqiang

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