Non-calcified ductal carcinoma in situ: Ultrasound and mammographic findings correlated with histological findings

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Abstract

Purpose: To evaluate radiological findings of non-calcified ductal carcinoma in situ (DCIS) and to correlate those with histological features. Materials and Methods: From July 2002 to March 2006, 22 patients with histologically-proven non-calcified DCIS were included. Mammography was obtained in 19 patients, ultrasound in 18 patients, and both examinations in 15 patients. Radiological findings were evaluated according to the Breast Imaging Reporting and Data System by American College of Radiology. Histological tumor subtype and Van Nuys classification of DCIS were assessed. Results: Histological subtypes consisted of mixed type in 11 patients (50%), comedo in 4 (18%), cribriform in 4 (18%), papillary type in 2 (9%), and solid in one (5%). According to Van Nuys classification, group 3 DCIS was observed in 13 (59%) patients. In the 19 patients who underwent mammography, 13 patients presented with abnormal findings: focal asymmetry in 7 patients (37%), masses in 4 (21%), skin thickening in one (5%), and architectural distortion in one (5%). In the 18 patients who had received breast ultrasound, a mass was present in 15 (83%) patients and ductal changes in 3 patients (17%). Sixty percent of patients with masses on ultrasound had group 3 DCIS and 100% of patients with ductal change had group 1 DCIS (p= 0.017). Conclusion: Diagnosis of non-calcified DCIS by mammography is not an easy task due to the lack of typical malignant calcifications or masses. High resolution ultrasound can be useful for detecting non-calcified DCIS, and ultrasound findings are correlated with histological features.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalYonsei Medical Journal
Volume49
Issue number1
DOIs
Publication statusPublished - 2008 Feb 1

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Carcinoma, Intraductal, Noninfiltrating
Mammography
Breast
Radiology
Information Systems

Keywords

  • Breast neoplams
  • Mammary ultrasonography
  • Mammography
  • Noninfiltrating intraductal carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{ccba345455374dfa8289d56543322b8f,
title = "Non-calcified ductal carcinoma in situ: Ultrasound and mammographic findings correlated with histological findings",
abstract = "Purpose: To evaluate radiological findings of non-calcified ductal carcinoma in situ (DCIS) and to correlate those with histological features. Materials and Methods: From July 2002 to March 2006, 22 patients with histologically-proven non-calcified DCIS were included. Mammography was obtained in 19 patients, ultrasound in 18 patients, and both examinations in 15 patients. Radiological findings were evaluated according to the Breast Imaging Reporting and Data System by American College of Radiology. Histological tumor subtype and Van Nuys classification of DCIS were assessed. Results: Histological subtypes consisted of mixed type in 11 patients (50{\%}), comedo in 4 (18{\%}), cribriform in 4 (18{\%}), papillary type in 2 (9{\%}), and solid in one (5{\%}). According to Van Nuys classification, group 3 DCIS was observed in 13 (59{\%}) patients. In the 19 patients who underwent mammography, 13 patients presented with abnormal findings: focal asymmetry in 7 patients (37{\%}), masses in 4 (21{\%}), skin thickening in one (5{\%}), and architectural distortion in one (5{\%}). In the 18 patients who had received breast ultrasound, a mass was present in 15 (83{\%}) patients and ductal changes in 3 patients (17{\%}). Sixty percent of patients with masses on ultrasound had group 3 DCIS and 100{\%} of patients with ductal change had group 1 DCIS (p= 0.017). Conclusion: Diagnosis of non-calcified DCIS by mammography is not an easy task due to the lack of typical malignant calcifications or masses. High resolution ultrasound can be useful for detecting non-calcified DCIS, and ultrasound findings are correlated with histological features.",
keywords = "Breast neoplams, Mammary ultrasonography, Mammography, Noninfiltrating intraductal carcinoma",
author = "Cho, {Kyu Ran} and Seo, {Bo Kyoung} and Kim, {Chul Hwan} and Whang, {Kyu Won} and Kim, {Yun Hwan} and Kim, {Baek Hyun} and Woo, {Ok Hee} and Lee, {Young Hen} and Chung, {Kyoo Byung}",
year = "2008",
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day = "1",
doi = "10.3349/ymj.2008.49.1.103",
language = "English",
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pages = "103--110",
journal = "Yonsei Medical Journal",
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T1 - Non-calcified ductal carcinoma in situ

T2 - Ultrasound and mammographic findings correlated with histological findings

AU - Cho, Kyu Ran

AU - Seo, Bo Kyoung

AU - Kim, Chul Hwan

AU - Whang, Kyu Won

AU - Kim, Yun Hwan

AU - Kim, Baek Hyun

AU - Woo, Ok Hee

AU - Lee, Young Hen

AU - Chung, Kyoo Byung

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Purpose: To evaluate radiological findings of non-calcified ductal carcinoma in situ (DCIS) and to correlate those with histological features. Materials and Methods: From July 2002 to March 2006, 22 patients with histologically-proven non-calcified DCIS were included. Mammography was obtained in 19 patients, ultrasound in 18 patients, and both examinations in 15 patients. Radiological findings were evaluated according to the Breast Imaging Reporting and Data System by American College of Radiology. Histological tumor subtype and Van Nuys classification of DCIS were assessed. Results: Histological subtypes consisted of mixed type in 11 patients (50%), comedo in 4 (18%), cribriform in 4 (18%), papillary type in 2 (9%), and solid in one (5%). According to Van Nuys classification, group 3 DCIS was observed in 13 (59%) patients. In the 19 patients who underwent mammography, 13 patients presented with abnormal findings: focal asymmetry in 7 patients (37%), masses in 4 (21%), skin thickening in one (5%), and architectural distortion in one (5%). In the 18 patients who had received breast ultrasound, a mass was present in 15 (83%) patients and ductal changes in 3 patients (17%). Sixty percent of patients with masses on ultrasound had group 3 DCIS and 100% of patients with ductal change had group 1 DCIS (p= 0.017). Conclusion: Diagnosis of non-calcified DCIS by mammography is not an easy task due to the lack of typical malignant calcifications or masses. High resolution ultrasound can be useful for detecting non-calcified DCIS, and ultrasound findings are correlated with histological features.

AB - Purpose: To evaluate radiological findings of non-calcified ductal carcinoma in situ (DCIS) and to correlate those with histological features. Materials and Methods: From July 2002 to March 2006, 22 patients with histologically-proven non-calcified DCIS were included. Mammography was obtained in 19 patients, ultrasound in 18 patients, and both examinations in 15 patients. Radiological findings were evaluated according to the Breast Imaging Reporting and Data System by American College of Radiology. Histological tumor subtype and Van Nuys classification of DCIS were assessed. Results: Histological subtypes consisted of mixed type in 11 patients (50%), comedo in 4 (18%), cribriform in 4 (18%), papillary type in 2 (9%), and solid in one (5%). According to Van Nuys classification, group 3 DCIS was observed in 13 (59%) patients. In the 19 patients who underwent mammography, 13 patients presented with abnormal findings: focal asymmetry in 7 patients (37%), masses in 4 (21%), skin thickening in one (5%), and architectural distortion in one (5%). In the 18 patients who had received breast ultrasound, a mass was present in 15 (83%) patients and ductal changes in 3 patients (17%). Sixty percent of patients with masses on ultrasound had group 3 DCIS and 100% of patients with ductal change had group 1 DCIS (p= 0.017). Conclusion: Diagnosis of non-calcified DCIS by mammography is not an easy task due to the lack of typical malignant calcifications or masses. High resolution ultrasound can be useful for detecting non-calcified DCIS, and ultrasound findings are correlated with histological features.

KW - Breast neoplams

KW - Mammary ultrasonography

KW - Mammography

KW - Noninfiltrating intraductal carcinoma

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