Non-convulsive seizure related to Cremophor EL™-free,polymeric micelle formulation of paclitaxel: A case report

Yoon Sun Shin, Kyung Jin Min, Seung Young Choi, Nak Woo Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-yearold woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrELfree, polymeric micelle formulation of paclitaxel. One week after her fourth round of chemotherapy, she experienced a transient episode of aphasia for 45 minutes. Electroencephalography demonstrated epileptiform discharges. To our knowledge, this is the first reported case of seizure associated with a CrEL-free formulation of paclitaxel. Although rare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of this paclitaxel formulation.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalObstetrics and Gynecology Science
Volume61
Issue number3
DOIs
Publication statusPublished - 2018 May 1

Keywords

  • Cremophor
  • Neurotoxicity
  • Paclitaxel
  • Seizures

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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