Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects

Da Hye Lee, Ji Sun Shin, Jin Su Lee, Shin Young Kang, Hee Soo Han, Seung Mok Ryu, Kyung Tae Lee, Dongho Lee, Dae Sik Jang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F–J (1–5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1–5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1–6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 μM, respectively.

Original languageEnglish
JournalArchives of Pharmacal Research
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Iridoid
  • Nitric oxide
  • Patrinia scabra
  • Patriscabrin
  • Valerianaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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