Non-Invasive Brain-to-Brain Interface (BBI)

Establishing Functional Links between Two Brains

Seung Schik Yoo, Hyungmin Kim, Emmanuel Filandrianos, Seyed Javid Taghados, Shin Suk Park

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Transcranial focused ultrasound (FUS) is capable of modulating the neural activity of specific brain regions, with a potential role as a non-invasive computer-to-brain interface (CBI). In conjunction with the use of brain-to-computer interface (BCI) techniques that translate brain function to generate computer commands, we investigated the feasibility of using the FUS-based CBI to non-invasively establish a functional link between the brains of different species (i.e. human and Sprague-Dawley rat), thus creating a brain-to-brain interface (BBI). The implementation was aimed to non-invasively translate the human volunteer's intention to stimulate a rat's brain motor area that is responsible for the tail movement. The volunteer initiated the intention by looking at a strobe light flicker on a computer display, and the degree of synchronization in the electroencephalographic steady-state-visual-evoked-potentials (SSVEP) with respect to the strobe frequency was analyzed using a computer. Increased signal amplitude in the SSVEP, indicating the volunteer's intention, triggered the delivery of a burst-mode FUS (350 kHz ultrasound frequency, tone burst duration of 0.5 ms, pulse repetition frequency of 1 kHz, given for 300 msec duration) to excite the motor area of an anesthetized rat transcranially. The successful excitation subsequently elicited the tail movement, which was detected by a motion sensor. The interface was achieved at 94.0±3.0% accuracy, with a time delay of 1.59±1.07 sec from the thought-initiation to the creation of the tail movement. Our results demonstrate the feasibility of a computer-mediated BBI that links central neural functions between two biological entities, which may confer unexplored opportunities in the study of neuroscience with potential implications for therapeutic applications.

Original languageEnglish
Article numbere60410
JournalPLoS One
Volume8
Issue number4
DOIs
Publication statusPublished - 2013 Apr 3

Fingerprint

Brain
brain
Brain-Computer Interfaces
Tail
Volunteers
Visual Evoked Potentials
Ultrasonics
Motor Cortex
Interfaces (computer)
volunteers
Rats
tail
evoked potentials
Bioelectric potentials
Telecommunication links
rats
Neurosciences
Sprague Dawley Rats
neurophysiology
duration

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Non-Invasive Brain-to-Brain Interface (BBI) : Establishing Functional Links between Two Brains. / Yoo, Seung Schik; Kim, Hyungmin; Filandrianos, Emmanuel; Taghados, Seyed Javid; Park, Shin Suk.

In: PLoS One, Vol. 8, No. 4, e60410, 03.04.2013.

Research output: Contribution to journalArticle

Yoo, Seung Schik ; Kim, Hyungmin ; Filandrianos, Emmanuel ; Taghados, Seyed Javid ; Park, Shin Suk. / Non-Invasive Brain-to-Brain Interface (BBI) : Establishing Functional Links between Two Brains. In: PLoS One. 2013 ; Vol. 8, No. 4.
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