Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1α mechanism

Sook Kyoung Kim, Hui Nam Pak, Jae Hyung Park, Jongil Choi, Myung-Hyun Nam, Yunjung Jo, Young Hoon Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

AimsIt has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1α pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism.Methods and resultsFifty-six patients (39 males, 53.0 ± 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (ΔCD34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1α decreased after RFCA and had no correlation with ΔCD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GROβ (P < 0.001) increased after RFCA and had correlations with 24 h ΔCD34+ cells.ConclusionNon-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1α pathway associated with MMP-9 and GROβ.

Original languageEnglish
Pages (from-to)1024-1031
Number of pages8
JournalEuropace
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

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Catheter Ablation
Stromal Cells
Atrial Fibrillation
Wounds and Injuries
Chemokine CXCL12
Matrix Metalloproteinase 9
Troponin I
Blood Cell Count
Electrophysiology
Bone Marrow Cells
Myocardial Ischemia

Keywords

  • Atrial fibrillation
  • Cardiac injury
  • Catheter ablation
  • CD34+ mononuclear cell

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

@article{5ec316ee366142c08ac3502271bcfef4,
title = "Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1α mechanism",
abstract = "AimsIt has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1α pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism.Methods and resultsFifty-six patients (39 males, 53.0 ± 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (ΔCD34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1α decreased after RFCA and had no correlation with ΔCD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GROβ (P < 0.001) increased after RFCA and had correlations with 24 h ΔCD34+ cells.ConclusionNon-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1α pathway associated with MMP-9 and GROβ.",
keywords = "Atrial fibrillation, Cardiac injury, Catheter ablation, CD34+ mononuclear cell",
author = "Kim, {Sook Kyoung} and Pak, {Hui Nam} and Park, {Jae Hyung} and Jongil Choi and Myung-Hyun Nam and Yunjung Jo and Kim, {Young Hoon}",
year = "2009",
month = "8",
day = "1",
doi = "10.1093/europace/eup185",
language = "English",
volume = "11",
pages = "1024--1031",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "8",

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TY - JOUR

T1 - Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1α mechanism

AU - Kim, Sook Kyoung

AU - Pak, Hui Nam

AU - Park, Jae Hyung

AU - Choi, Jongil

AU - Nam, Myung-Hyun

AU - Jo, Yunjung

AU - Kim, Young Hoon

PY - 2009/8/1

Y1 - 2009/8/1

N2 - AimsIt has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1α pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism.Methods and resultsFifty-six patients (39 males, 53.0 ± 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (ΔCD34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1α decreased after RFCA and had no correlation with ΔCD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GROβ (P < 0.001) increased after RFCA and had correlations with 24 h ΔCD34+ cells.ConclusionNon-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1α pathway associated with MMP-9 and GROβ.

AB - AimsIt has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1α pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism.Methods and resultsFifty-six patients (39 males, 53.0 ± 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (ΔCD34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1α decreased after RFCA and had no correlation with ΔCD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GROβ (P < 0.001) increased after RFCA and had correlations with 24 h ΔCD34+ cells.ConclusionNon-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1α pathway associated with MMP-9 and GROβ.

KW - Atrial fibrillation

KW - Cardiac injury

KW - Catheter ablation

KW - CD34+ mononuclear cell

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U2 - 10.1093/europace/eup185

DO - 10.1093/europace/eup185

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VL - 11

SP - 1024

EP - 1031

JO - Europace

JF - Europace

SN - 1099-5129

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