Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

Research output: Contribution to journalReview article

188 Citations (Scopus)

Abstract

Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the peripheral tissues in humans, and could cause severe metabolic disorders by inducing accumulation of lipid in the liver, resulting in the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD, which is characterized by increased fat depots in the liver, could precede more severe diseases such as non-alcoholic steatohepatitis (NASH), cirrhosis, and in some cases hepatocellular carcinoma. Accumulation of lipid in the liver can be traced by increased uptake of free fatty acids into the liver, impaired fatty acid beta oxidation, or the increased incidence of de novo lipogenesis. In this review, I would like to focus on the roles of individual pathways that contribute to the hepatic steatosis as a precursor for the NAFLD.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalClinical and Molecular Hepatology
Volume19
Issue number3
DOIs
Publication statusPublished - 2013 Sep 1

Keywords

  • De novo lipogenesis
  • Fatty acid beta oxidation
  • Free fatty acids
  • TG secretion

ASJC Scopus subject areas

  • Hepatology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis'. Together they form a unique fingerprint.

  • Cite this