Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease

Min Seok Kim; Han Yeong Jeong; Kwan Hyuk Cho; Seung Won Oh; Seong Jun Byun; Se Joon Woo; Hee Kyung Yang; Jeong Min Hwang; Kyu Hyung Park; Chi Kyung Kim; Sang Jun Park

doi:10.1371/journal.pone.0225322

Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease

Min Seok Kim, Han Yeong Jeong, Kwan Hyuk Cho, Seung Won Oh, Seong Jun Byun, Se Joon Woo, Hee Kyung Yang, Jeong Min Hwang, Kyu Hyung Park, Chi Kyung Kim, Sang Jun Park

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

Original language	English
Article number	e0225322
Journal	PloS one
Volume	14
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0225322
Publication status	Published - 2019 Nov 1

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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This output contributes to the following Sustainable Development Goal(s)

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Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease. / Kim, Min Seok; Jeong, Han Yeong; Cho, Kwan Hyuk; Oh, Seung Won; Byun, Seong Jun; Woo, Se Joon; Yang, Hee Kyung; Hwang, Jeong Min; Park, Kyu Hyung; Kim, Chi Kyung; Park, Sang Jun.

In: PloS one, Vol. 14, No. 11, e0225322, 01.11.2019.

Research output: Contribution to journal › Article › peer-review

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title = "Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease",

abstract = "We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.",

author = "Kim, {Min Seok} and Jeong, {Han Yeong} and Cho, {Kwan Hyuk} and Oh, {Seung Won} and Byun, {Seong Jun} and Woo, {Se Joon} and Yang, {Hee Kyung} and Hwang, {Jeong Min} and Park, {Kyu Hyung} and Kim, {Chi Kyung} and Park, {Sang Jun}",

note = "Funding Information: This study was supported by the Busan Sungmo Eye Hospital 2016 Sodam scholarship committee, and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2019M3E5D1A01068991). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

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AU - Kim, Min Seok

AU - Jeong, Han Yeong

AU - Cho, Kwan Hyuk

AU - Oh, Seung Won

AU - Byun, Seong Jun

AU - Woo, Se Joon

AU - Yang, Hee Kyung

AU - Hwang, Jeong Min

AU - Park, Kyu Hyung

AU - Kim, Chi Kyung

AU - Park, Sang Jun

N1 - Funding Information: This study was supported by the Busan Sungmo Eye Hospital 2016 Sodam scholarship committee, and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2019M3E5D1A01068991). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2019 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

AB - We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

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SN - 1932-6203

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M1 - e0225322

ER -

Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease

Abstract

ASJC Scopus subject areas

UN SDGs

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