Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease

Min Seok Kim, Han Yeong Jeong, Kwan Hyuk Cho, Seung Won Oh, Seong Jun Byun, Se Joon Woo, Hee Kyung Yang, Jeong Min Hwang, Kyu Hyung Park, Chi Kyung Kim, Sang Jun Park

Research output: Contribution to journalArticle

Abstract

We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

Original languageEnglish
Article numbere0225322
JournalPloS one
Volume14
Issue number11
DOIs
Publication statusPublished - 2019 Jan 1

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Cerebral Small Vessel Diseases
Ischemic Optic Neuropathy
peripheral nervous system diseases
optics
Optics
Magnetic resonance
magnetic resonance imaging
Brain
Magnetic Resonance Imaging
eye diseases
brain
Imaging techniques
medical history
nervous system diseases
Eye Diseases
gender
hyperlipidemia
Medical problems
Dyslipidemias
Nervous System Diseases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kim, M. S., Jeong, H. Y., Cho, K. H., Oh, S. W., Byun, S. J., Woo, S. J., ... Park, S. J. (2019). Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease. PloS one, 14(11), [e0225322]. https://doi.org/10.1371/journal.pone.0225322

Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease. / Kim, Min Seok; Jeong, Han Yeong; Cho, Kwan Hyuk; Oh, Seung Won; Byun, Seong Jun; Woo, Se Joon; Yang, Hee Kyung; Hwang, Jeong Min; Park, Kyu Hyung; Kim, Chi Kyung; Park, Sang Jun.

In: PloS one, Vol. 14, No. 11, e0225322, 01.01.2019.

Research output: Contribution to journalArticle

Kim, MS, Jeong, HY, Cho, KH, Oh, SW, Byun, SJ, Woo, SJ, Yang, HK, Hwang, JM, Park, KH, Kim, CK & Park, SJ 2019, 'Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease', PloS one, vol. 14, no. 11, e0225322. https://doi.org/10.1371/journal.pone.0225322
Kim, Min Seok ; Jeong, Han Yeong ; Cho, Kwan Hyuk ; Oh, Seung Won ; Byun, Seong Jun ; Woo, Se Joon ; Yang, Hee Kyung ; Hwang, Jeong Min ; Park, Kyu Hyung ; Kim, Chi Kyung ; Park, Sang Jun. / Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease. In: PloS one. 2019 ; Vol. 14, No. 11.
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