Abstract
We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.
| Original language | English |
|---|---|
| Article number | e0225322 |
| Journal | PloS one |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- General
Cite this
Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease. / Kim, Min Seok; Jeong, Han Yeong; Cho, Kwan Hyuk; Oh, Seung Won; Byun, Seong Jun; Woo, Se Joon; Yang, Hee Kyung; Hwang, Jeong Min; Park, Kyu Hyung; Kim, Chi Kyung; Park, Sang Jun.
In: PloS one, Vol. 14, No. 11, e0225322, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
AU - Kim, Min Seok
AU - Jeong, Han Yeong
AU - Cho, Kwan Hyuk
AU - Oh, Seung Won
AU - Byun, Seong Jun
AU - Woo, Se Joon
AU - Yang, Hee Kyung
AU - Hwang, Jeong Min
AU - Park, Kyu Hyung
AU - Kim, Chi Kyung
AU - Park, Sang Jun
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.
AB - We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.
UR - http://www.scopus.com/inward/record.url?scp=85075039215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075039215&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0225322
DO - 10.1371/journal.pone.0225322
M3 - Article
C2 - 31725805
AN - SCOPUS:85075039215
VL - 14
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e0225322
ER -