Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent

Yong Il Park; Jeong Hyun Kim; Kang Taek Lee; Ki Seok Jeon; Hyon Bin Na; Jung Ho Yu; Hyung Min Kim; Nohyun Lee; Seung Hong Choi; Sung Il Baik; Hyoungsu Kim; Seung Pyo Park; Beom Jin Park; Young Woon Kim; Sung Ho Lee; Soo Young Yoon; In Chan Song; Woo Kyung Moon; Yung Doug Suh; Taeghwan Hyeon

doi:10.1002/adma.200901356

Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent

Yong Il Park, Jeong Hyun Kim, Kang Taek Lee, Ki Seok Jeon, Hyon Bin Na, Jung Ho Yu, Hyung Min Kim, Nohyun Lee, Seung Hong Choi, Sung Il Baik, Hyoungsu Kim, Seung Pyo Park, Beom Jin Park, Young Woon Kim, Sung Ho Lee, Soo Young Yoon, In Chan Song, Woo Kyung Moon, Yung Doug Suh, Taeghwan Hyeon

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

538 Citations (Scopus)

Abstract

(Figure Presented) Core/shell upconverting nanoparticles (UCNPs) of NaGdF₄:Er³⁺,Yb³⁺/NaGdF₄ (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd³⁺ ions in the host matrix, contrast is enhanced in T₁-weighted MRI.

Original language	English
Pages (from-to)	4467-4471
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	44
DOIs	https://doi.org/10.1002/adma.200901356
Publication status	Published - 2009 Nov 26

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Park, Y. I., Kim, J. H., Lee, K. T., Jeon, K. S., Na, H. B., Yu, J. H., Kim, H. M., Lee, N., Choi, S. H., Baik, S. I., Kim, H., Park, S. P., Park, B. J., Kim, Y. W., Lee, S. H., Yoon, S. Y., Song, I. C., Moon, W. K., Suh, Y. D., & Hyeon, T. (2009). Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent. Advanced Materials, 21(44), 4467-4471. https://doi.org/10.1002/adma.200901356

Park, YI, Kim, JH, Lee, KT, Jeon, KS, Na, HB, Yu, JH, Kim, HM, Lee, N, Choi, SH, Baik, SI, Kim, H, Park, SP, Park, BJ, Kim, YW, Lee, SH, Yoon, SY, Song, IC, Moon, WK, Suh, YD & Hyeon, T 2009, 'Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent', Advanced Materials, vol. 21, no. 44, pp. 4467-4471. https://doi.org/10.1002/adma.200901356

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title = "Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent",

abstract = "(Figure Presented) Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd3+ ions in the host matrix, contrast is enhanced in T1-weighted MRI.",

author = "Park, {Yong Il} and Kim, {Jeong Hyun} and Lee, {Kang Taek} and Jeon, {Ki Seok} and Na, {Hyon Bin} and Yu, {Jung Ho} and Kim, {Hyung Min} and Nohyun Lee and Choi, {Seung Hong} and Baik, {Sung Il} and Hyoungsu Kim and Park, {Seung Pyo} and Park, {Beom Jin} and Kim, {Young Woon} and Lee, {Sung Ho} and Yoon, {Soo Young} and Song, {In Chan} and Moon, {Woo Kyung} and Suh, {Yung Doug} and Taeghwan Hyeon",

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AU - Park, Yong Il

AU - Kim, Jeong Hyun

AU - Lee, Kang Taek

AU - Jeon, Ki Seok

AU - Na, Hyon Bin

AU - Yu, Jung Ho

AU - Kim, Hyung Min

AU - Lee, Nohyun

AU - Choi, Seung Hong

AU - Baik, Sung Il

AU - Kim, Hyoungsu

AU - Park, Seung Pyo

AU - Park, Beom Jin

AU - Kim, Young Woon

AU - Lee, Sung Ho

AU - Yoon, Soo Young

AU - Song, In Chan

AU - Moon, Woo Kyung

AU - Suh, Yung Doug

AU - Hyeon, Taeghwan

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AB - (Figure Presented) Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd3+ ions in the host matrix, contrast is enhanced in T1-weighted MRI.

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Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent

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