Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, Michael S. Feld

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

Original languageEnglish
Pages (from-to)2028-2030
Number of pages3
JournalOptics Letters
Volume29
Issue number17
DOIs
Publication statusPublished - 2004 Sep 1
Externally publishedYes

Fingerprint

nerves
Action Potentials
interferometers
bundles
cells
scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer. / Fang-Yen, Christopher; Chu, Mark C.; Seung, H. Sebastian; Dasari, Ramachandra R.; Feld, Michael S.

In: Optics Letters, Vol. 29, No. 17, 01.09.2004, p. 2028-2030.

Research output: Contribution to journalArticle

Fang-Yen, Christopher ; Chu, Mark C. ; Seung, H. Sebastian ; Dasari, Ramachandra R. ; Feld, Michael S. / Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer. In: Optics Letters. 2004 ; Vol. 29, No. 17. pp. 2028-2030.
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