Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, Michael S. Feld

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We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

Original languageEnglish
Pages (from-to)2028-2030
Number of pages3
JournalOptics Letters
Issue number17
Publication statusPublished - 2004 Sep 1
Externally publishedYes


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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