Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz, Hongjie Dai

Research output: Contribution to journalArticle

1279 Citations (Scopus)

Abstract

Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

Original languageEnglish
Pages (from-to)4984-4989
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number9
DOIs
Publication statusPublished - 2003 Apr 29
Externally publishedYes

Fingerprint

Nanotubes
Carbon Nanotubes
Biosensing Techniques
Nanotechnology
Nanostructures
Protein Binding
Immobilization
Biological Assay
Autoimmune Diseases
Carrier Proteins
Membrane Proteins
Proteins
Equipment and Supplies
Antibodies

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. / Chen, Robert J.; Bangsaruntip, Sarunya; Drouvalakis, Katerina A.; Wong Shi Kam, Nadine; Shim, Moonsub; Li, Yiming; Kim, Woong; Utz, Paul J.; Dai, Hongjie.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 9, 29.04.2003, p. 4984-4989.

Research output: Contribution to journalArticle

Chen, Robert J. ; Bangsaruntip, Sarunya ; Drouvalakis, Katerina A. ; Wong Shi Kam, Nadine ; Shim, Moonsub ; Li, Yiming ; Kim, Woong ; Utz, Paul J. ; Dai, Hongjie. / Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. In: Proceedings of the National Academy of Sciences of the United States of America. 2003 ; Vol. 100, No. 9. pp. 4984-4989.
@article{dfbf7b28d481412db08729c3740f745c,
title = "Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors",
abstract = "Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.",
author = "Chen, {Robert J.} and Sarunya Bangsaruntip and Drouvalakis, {Katerina A.} and {Wong Shi Kam}, Nadine and Moonsub Shim and Yiming Li and Woong Kim and Utz, {Paul J.} and Hongjie Dai",
year = "2003",
month = "4",
day = "29",
doi = "10.1073/pnas.0837064100",
language = "English",
volume = "100",
pages = "4984--4989",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "9",

}

TY - JOUR

T1 - Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

AU - Chen, Robert J.

AU - Bangsaruntip, Sarunya

AU - Drouvalakis, Katerina A.

AU - Wong Shi Kam, Nadine

AU - Shim, Moonsub

AU - Li, Yiming

AU - Kim, Woong

AU - Utz, Paul J.

AU - Dai, Hongjie

PY - 2003/4/29

Y1 - 2003/4/29

N2 - Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

AB - Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

UR - http://www.scopus.com/inward/record.url?scp=0037967030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037967030&partnerID=8YFLogxK

U2 - 10.1073/pnas.0837064100

DO - 10.1073/pnas.0837064100

M3 - Article

C2 - 12697899

AN - SCOPUS:0037967030

VL - 100

SP - 4984

EP - 4989

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 9

ER -