Noninvasive assessment of hepatic sinusoidal obstructive syndrome using acoustic radiation force impulse elastography imaging: A proof-of-concept study in rat models

So Hyun Park, Seung Soo Lee, Ji Youn Sung, Kiyong Na, Hyoung Jung Kim, So Yeon Kim, Beomjin Park, Jae Ho Byun

Research output: Contribution to journalArticle

9 Citations (Scopus)


Objectives: To determine the feasibility of acoustic radiation force impulse (ARFI) elastography in the evaluation of hepatic sinusoidal obstruction syndrome (SOS) in rat models. Methods: Rat SOS models of various severities were created by monocrotaline gavage (n = 40) or by intraperitoneal injection of 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) (n = 16). Liver shear-wave velocity (SWV) was measured using ARFI elastography. Liver samples were analysed for the SOS score, steatosis, lobular inflammation and fibrosis. Results: The liver SWV was significantly elevated in the SOS models (1.29–2.24 m/s) compared with that of the matched control rats (1.01–1.09; p≤.09; veFor seven FOLFOX-treated rats which were longitudinally followed-up, the liver SWV significantly increased at 7 weeks (1.32±0.13 m/s) compared with the baseline (1.08±0.1 m/s, p=.015) and then significantly declined after a 2-week, treatment-free period (1.15±0.13 m/s; p=.048). Multivariate analysis revealed that the SOS score (p<.001) and lobular inflammation (p=.044) were independently correlated with the liver SWV. Conclusion: Liver SWV is elevated in SOS in proportion to the degree of sinusoidal injury and lobular inflammation in rat SOS models. ARFI elastography has potential as an examination for diagnosis, severity assessment and follow-up of SOS. Key Points: • Liver SWV using ARFI elastography was significantly elevated in SOS rat.• Sinusoidal injury and lobular inflammation grades had correlation with liver SWV.• ARFI elastography has potential for diagnosis, severity assessment, and follow-up of SOS.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalEuropean Radiology
Publication statusAccepted/In press - 2017 Dec 7



  • Acoustic radiation force impulse elastography
  • Liver
  • Shear-wave velocity
  • Sinusoidal obstruction syndrome
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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