Abstract
Background Recently, the definition of essential tremor (ET) has evolved to have two different meanings. One refers to classic ET, a benign mono-symptomatic disorder, and the other refers to a heterogeneous neurodegenerative disorder. The aim of this study was to categorize nonmotor symptoms according to ET phenotype, and compare them, along with autonomic function, in people with Parkinson's disease (PD) and normal controls. Methods We divided patients with ET into 3 subtypes according to their motor features: 23 Pure-ET, 25 Cerebellar-ET, and 12 Parkinsonism-ET. Comparisons were made between 30 PD subjects and 22 normal controls, and 60 subjects with ET. The following assessments were conducted: the Nonmotor Symptoms Scale, the Mini-Mental State Exam, Montreal Cognitive Assessment, the Montgomery-Asberg Depression Rating Scale, Neuropsychiatric Inventory Questionnaire, Beck Anxiety Inventory, the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and the Scales for Outcomes in Parkinson's Disease - Autonomic. Results There were significant differences in the Nonmotor Symptoms Scale total scores of the ET, PD, and control groups (ET: 25.500 ± 2.346; PD: 27.960 ± 3.267; Control: 3.328 ± 3.796.). There were no significant differences in terms of each ET phenotype. ET patients had significant cognitive dysfunction, neuropsychiatric problems including depression and have complained about significant autonomic dysfunction and excessive daytime somnolence compared to normal controls. Conclusions Patients with ET have several nonmotor symptoms similar to those of patients with PD, which have a similar impact on their quality of life. Therefore, nonmotor symptoms should be considered in the clinical evaluation and management of ET.
| Original language | English |
|---|---|
| Pages (from-to) | 168-173 |
| Number of pages | 6 |
| Journal | Journal of the Neurological Sciences |
| Volume | 349 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2015 Feb 15 |
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Keywords
- Depression
- Essential tremor
- Nonmotor symptoms
- Parkinson's disease
- Quality of life
- Sleep
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Nonmotor symptoms in essential tremor : Comparison with Parkinson's disease and normal control. / Lee, Seon Min; Kim, Minjik; Lee, Hye Mi; Kwon, Kyum Yil; Koh, Seong Beom.
In: Journal of the Neurological Sciences, Vol. 349, No. 1-2, 15.02.2015, p. 168-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonmotor symptoms in essential tremor
T2 - Comparison with Parkinson's disease and normal control
AU - Lee, Seon Min
AU - Kim, Minjik
AU - Lee, Hye Mi
AU - Kwon, Kyum Yil
AU - Koh, Seong Beom
PY - 2015/2/15
Y1 - 2015/2/15
N2 - Background Recently, the definition of essential tremor (ET) has evolved to have two different meanings. One refers to classic ET, a benign mono-symptomatic disorder, and the other refers to a heterogeneous neurodegenerative disorder. The aim of this study was to categorize nonmotor symptoms according to ET phenotype, and compare them, along with autonomic function, in people with Parkinson's disease (PD) and normal controls. Methods We divided patients with ET into 3 subtypes according to their motor features: 23 Pure-ET, 25 Cerebellar-ET, and 12 Parkinsonism-ET. Comparisons were made between 30 PD subjects and 22 normal controls, and 60 subjects with ET. The following assessments were conducted: the Nonmotor Symptoms Scale, the Mini-Mental State Exam, Montreal Cognitive Assessment, the Montgomery-Asberg Depression Rating Scale, Neuropsychiatric Inventory Questionnaire, Beck Anxiety Inventory, the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and the Scales for Outcomes in Parkinson's Disease - Autonomic. Results There were significant differences in the Nonmotor Symptoms Scale total scores of the ET, PD, and control groups (ET: 25.500 ± 2.346; PD: 27.960 ± 3.267; Control: 3.328 ± 3.796.). There were no significant differences in terms of each ET phenotype. ET patients had significant cognitive dysfunction, neuropsychiatric problems including depression and have complained about significant autonomic dysfunction and excessive daytime somnolence compared to normal controls. Conclusions Patients with ET have several nonmotor symptoms similar to those of patients with PD, which have a similar impact on their quality of life. Therefore, nonmotor symptoms should be considered in the clinical evaluation and management of ET.
AB - Background Recently, the definition of essential tremor (ET) has evolved to have two different meanings. One refers to classic ET, a benign mono-symptomatic disorder, and the other refers to a heterogeneous neurodegenerative disorder. The aim of this study was to categorize nonmotor symptoms according to ET phenotype, and compare them, along with autonomic function, in people with Parkinson's disease (PD) and normal controls. Methods We divided patients with ET into 3 subtypes according to their motor features: 23 Pure-ET, 25 Cerebellar-ET, and 12 Parkinsonism-ET. Comparisons were made between 30 PD subjects and 22 normal controls, and 60 subjects with ET. The following assessments were conducted: the Nonmotor Symptoms Scale, the Mini-Mental State Exam, Montreal Cognitive Assessment, the Montgomery-Asberg Depression Rating Scale, Neuropsychiatric Inventory Questionnaire, Beck Anxiety Inventory, the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and the Scales for Outcomes in Parkinson's Disease - Autonomic. Results There were significant differences in the Nonmotor Symptoms Scale total scores of the ET, PD, and control groups (ET: 25.500 ± 2.346; PD: 27.960 ± 3.267; Control: 3.328 ± 3.796.). There were no significant differences in terms of each ET phenotype. ET patients had significant cognitive dysfunction, neuropsychiatric problems including depression and have complained about significant autonomic dysfunction and excessive daytime somnolence compared to normal controls. Conclusions Patients with ET have several nonmotor symptoms similar to those of patients with PD, which have a similar impact on their quality of life. Therefore, nonmotor symptoms should be considered in the clinical evaluation and management of ET.
KW - Depression
KW - Essential tremor
KW - Nonmotor symptoms
KW - Parkinson's disease
KW - Quality of life
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84923991433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923991433&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2015.01.012
DO - 10.1016/j.jns.2015.01.012
M3 - Article
C2 - 25641389
AN - SCOPUS:84923991433
VL - 349
SP - 168
EP - 173
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -