Nonspecific adsorption minimized nanomechanical immunoassay for application to assay using the real sample

Kyo Seon Hwang, Sang Myung Lee, Byung Hak Cha, Sang Kyung Kim, Jung Ho Park, Tae Song Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report an application feasibility of the dynamic microcantilever to detect the specific protein in human serum. The mechanical response (i.e. resonant frequency) change of functionalized dynamic microcantilever generated by biomolecular interactions allows one to detect the biomolecules of small amount without labeling process. We implemented the label-free detection of PSA in human serum like sample (protein mixture sample). The range of detected PSA was 1 and 10 ng/ml in clinical concentration range. It is suggest that the dynamic microcantilever enables one to apply the sensitive label-free detection of disease marker proteins in a real human sample.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1267-1269
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period07/10/707/10/11

Keywords

  • Clinical range
  • Microcantilever
  • PSA
  • Real sample

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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