Norfloxacin-releasing urethral catheter for long-term catheterization

Jae Hyung Park, Yong Woo Cho, Yong Hyun Cho, Joong Myung Choi, Hee Jong Shin, You Han Bae, Hesson Chung, Seo Young Jeong, Ick Chan Kwon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Norfloxacin-releasing urethral catheters were prepared for the purpose of preventing urinary tract infections during long-term catheterization. The outer and inner surfaces of the catheters were coated with poly(ethylene-co-vinyl acetate) (EVA) and an amphiphilic multiblock co-polymer (PEO2kPDMS), composed of poly(ethylene oxide) and poly(dimethyl siloxane). Norfloxacin, a fluoroquinolone synthetic antibiotic, was impregnated into a coating layer. The in vitro drug release behavior was monitored for 30 days, the surface topography was investigated using scanning electron microscopy (SEM) and the antibacterial activity against different bacteria implicated in urinary tract infection was evaluated by the in vitro inhibition zone test. All the coated catheters showed continuous delivery of norfloxacin for up to 30 days owing to hydrophobic natures of norfloxacin and EVA. PEO2kPDMS incorporated in a coating layer produced a smooth and uniform surface. The coated catheters created considerable inhibition zones for 10 days against Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris, indicating the continuous release of norfloxacin. Overall, it was evident that the catheters coated with EVA/PEO2kPDMS blends containing norfloxacin have a promising potential for the clinical use in patients undergoing long-term catheterization.

Original languageEnglish
Pages (from-to)951-962
Number of pages12
JournalJournal of Biomaterials Science, Polymer Edition
Volume14
Issue number9
DOIs
Publication statusPublished - 2003

Keywords

  • Controlled release
  • EVA
  • Inhibition zone
  • Long-term catheterization
  • Multiblock co-polymer
  • Norfloxacin
  • Urethral catheter

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Park, J. H., Cho, Y. W., Cho, Y. H., Choi, J. M., Shin, H. J., Bae, Y. H., Chung, H., Jeong, S. Y., & Kwon, I. C. (2003). Norfloxacin-releasing urethral catheter for long-term catheterization. Journal of Biomaterials Science, Polymer Edition, 14(9), 951-962. https://doi.org/10.1163/156856203322381438