Abstract
Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Biomaterials |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1997 Jan 1 |
| Externally published | Yes |
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Keywords
- Anti-calcification
- Sulphonated PEO
- Tissue modification
- Tissue valve
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Cite this
Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide). / Park, Ki Dong; Lee, Won Kyu; Yun, Ju Young; Han, Dong Keun; Kim, Soo Hyun; Kim, Young Ha; Kim, Hyoung Mook; Kim, Kwang Taek.
In: Biomaterials, Vol. 18, No. 1, 01.01.1997, p. 47-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)
AU - Park, Ki Dong
AU - Lee, Won Kyu
AU - Yun, Ju Young
AU - Han, Dong Keun
AU - Kim, Soo Hyun
AU - Kim, Young Ha
AU - Kim, Hyoung Mook
AU - Kim, Kwang Taek
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
AB - Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
KW - Anti-calcification
KW - Sulphonated PEO
KW - Tissue modification
KW - Tissue valve
UR - http://www.scopus.com/inward/record.url?scp=0031014822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031014822&partnerID=8YFLogxK
U2 - 10.1016/S0142-9612(96)00096-8
DO - 10.1016/S0142-9612(96)00096-8
M3 - Article
VL - 18
SP - 47
EP - 51
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 1
ER -