Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)

Ki Dong Park; Won Kyu Lee; Ju Young Yun; Dong Keun Han; Soo Hyun Kim; Young Ha Kim; Hyoung Mook Kim; Kwang Taek Kim

doi:10.1016/S0142-9612(96)00096-8

Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)

Ki Dong Park, Won Kyu Lee, Ju Young Yun, Dong Keun Han, Soo Hyun Kim, Young Ha Kim, Hyoung Mook Kim, Kwang Taek Kim

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO₃) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO₃] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO₃ than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO₃ can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO₃ groups after the covalent binding of PEG-SO₃ to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Biomaterials
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/S0142-9612(96)00096-8
Publication status	Published - 1997 Jan
Externally published	Yes

Keywords

Anti-calcification
Sulphonated PEO
Tissue modification
Tissue valve

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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title = "Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)",

abstract = "Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.",

keywords = "Anti-calcification, Sulphonated PEO, Tissue modification, Tissue valve",

author = "Park, {Ki Dong} and Lee, {Won Kyu} and Yun, {Ju Young} and Han, {Dong Keun} and Kim, {Soo Hyun} and Kim, {Young Ha} and Kim, {Hyoung Mook} and Kim, {Kwang Taek}",

note = "Funding Information: This study was supported by Korea MOST grants VO0134 and N12314.",

year = "1997",

month = jan,

doi = "10.1016/S0142-9612(96)00096-8",

language = "English",

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AU - Park, Ki Dong

AU - Lee, Won Kyu

AU - Yun, Ju Young

AU - Han, Dong Keun

AU - Kim, Soo Hyun

AU - Kim, Young Ha

AU - Kim, Hyoung Mook

AU - Kim, Kwang Taek

N1 - Funding Information: This study was supported by Korea MOST grants VO0134 and N12314.

PY - 1997/1

Y1 - 1997/1

N2 - Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.

AB - Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.

KW - Anti-calcification

KW - Sulphonated PEO

KW - Tissue modification

KW - Tissue valve

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Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)

Abstract

Keywords

ASJC Scopus subject areas

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