Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)

Ki Dong Park, Won Kyu Lee, Ju Young Yun, Dong Keun Han, Soo Hyun Kim, Young Ha Kim, Hyoung Mook Kim, Kwang Taek Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalBiomaterials
Volume18
Issue number1
DOIs
Publication statusPublished - 1997 Jan
Externally publishedYes

Keywords

  • Anti-calcification
  • Sulphonated PEO
  • Tissue modification
  • Tissue valve

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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  • Cite this

    Park, K. D., Lee, W. K., Yun, J. Y., Han, D. K., Kim, S. H., Kim, Y. H., Kim, H. M., & Kim, K. T. (1997). Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide). Biomaterials, 18(1), 47-51. https://doi.org/10.1016/S0142-9612(96)00096-8