Abstract
Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
Original language | English |
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Pages (from-to) | 47-51 |
Number of pages | 5 |
Journal | Biomaterials |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1997 Jan |
Keywords
- Anti-calcification
- Sulphonated PEO
- Tissue modification
- Tissue valve
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Ceramics and Composites
- Biomaterials
- Mechanics of Materials