Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12

Miri Lee, Hyeonji Park, Sea Wha Jeon, JeongKyu K. Bang, Ka Young Chung, DalWoong Choi, EunJoo J. Kim, Kyung Min Lim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Diverse compound sources are being explored for de-pigmentation activities to develop novel therapeutic agents or functional cosmetic ingredients for hyper-pigmentation disorders. Peptoids are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, instead of α-carbon. Peptoids are more durable against proteolysis and are being actively investigated in drug discovery, but rarely studied as cosmetic ingredients. Here, we demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model (Neoderm®-ME, Tegoscience Co) and zebrafish. Anti-melanogenic effects of PAL-10 or PAL-12 as compared with arbutin, a positive control in B16F10 cells, Neoderm®-ME and zebrafish were statistically significant and concentration-dependent anti-melanogenic effects were manifested as determined by image, histology, and melanin contents. Anti-melanogenic effects of PAL-10 appeared to be from enzymatic inhibition of tyrosinase while mRNA expression of melanogenic enzymes was not affected. In conclusion, we demonstrated that PAL-10 and PAL-12 can be used as a new cosmetic ingredient with strong brightening efficacies.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalArchives of Dermatological Research
Volume307
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Peptoids
Cosmetics
Zebrafish
Pigmentation Disorders
Arbutin
Peptidomimetics
Monophenol Monooxygenase
Melanins
Pigmentation
Drug Discovery
Proteolysis
Melanoma
Histology
Nitrogen
Carbon
Messenger RNA
Skin
Peptides
Enzymes
Therapeutics

Keywords

  • 3D human skin models
  • Melanogenesis
  • Peptoid
  • Tyrosinase
  • Zebrafish

ASJC Scopus subject areas

  • Dermatology

Cite this

Lee, M., Park, H., Jeon, S. W., Bang, J. K., Chung, K. Y., Choi, D., ... Lim, K. M. (2015). Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12. Archives of Dermatological Research, 307(3), 249-257. https://doi.org/10.1007/s00403-015-1555-1

Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12. / Lee, Miri; Park, Hyeonji; Jeon, Sea Wha; Bang, JeongKyu K.; Chung, Ka Young; Choi, DalWoong; Kim, EunJoo J.; Lim, Kyung Min.

In: Archives of Dermatological Research, Vol. 307, No. 3, 2015, p. 249-257.

Research output: Contribution to journalArticle

Lee, M, Park, H, Jeon, SW, Bang, JK, Chung, KY, Choi, D, Kim, EJ & Lim, KM 2015, 'Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12', Archives of Dermatological Research, vol. 307, no. 3, pp. 249-257. https://doi.org/10.1007/s00403-015-1555-1
Lee, Miri ; Park, Hyeonji ; Jeon, Sea Wha ; Bang, JeongKyu K. ; Chung, Ka Young ; Choi, DalWoong ; Kim, EunJoo J. ; Lim, Kyung Min. / Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12. In: Archives of Dermatological Research. 2015 ; Vol. 307, No. 3. pp. 249-257.
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