Novel connections and gaps in ethylene signaling from the ER membrane to the nucleus

Young Hee Cho, Sang-Dong Yoo

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The signaling of the plant hormone ethylene has been studied genetically, resulting in the identification of signaling components from membrane receptors to nuclear effectors. Among constituents of the hormone signaling pathway, functional links involving a putative mitogen-activated protein kinase kinase CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) and a membrane transporter-like protein ETHYLENE INSENSITIVE2 (EIN2) have been missing for a long time. We now learn that EIN2 is cleaved and its C-terminal end moves to the nucleus upon ethylene perception at the membrane receptors, and then the C-terminal end of EIN2 in the nucleus supports EIN3-dependent ethylene-response gene expression. CTR1 kinase activity negatively controls the EIN2 cleavage process through direct phosphorylation. Despite the novel connection of CTR1 with EIN2 that explains a large portion of the missing links in ethylene signaling, our understanding still remains far from its completion. This focused review will summarize recent advances in the EIN3-dependent ethylene signaling mechanisms including CTR1-EIN2 functions with respect to EIN3 regulation and ethylene responses. This will also present several emerging issues that need to be addressed for the comprehensive understanding of signaling pathways of the invaluable plant hormone ethylene.

Original languageEnglish
Article number733
JournalFrontiers in Plant Science
Volume5
Issue numberJAN
DOIs
Publication statusPublished - 2015 Jan 5

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ethylene
plant hormones
mitogen-activated protein kinase kinase
receptors
transporters
phosphorylation
phosphotransferases (kinases)
hormones
gene expression
proteins

Keywords

  • CTR1
  • EIN2
  • EIN3
  • Ethylene
  • MAPkinasekinaseKinase
  • Signaling

ASJC Scopus subject areas

  • Plant Science

Cite this

Novel connections and gaps in ethylene signaling from the ER membrane to the nucleus. / Cho, Young Hee; Yoo, Sang-Dong.

In: Frontiers in Plant Science, Vol. 5, No. JAN, 733, 05.01.2015.

Research output: Contribution to journalArticle

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