Novel function of stabilin-2 in myoblast fusion: the recognition of extracellular phosphatidylserine as a "fuse-me" signal

Go Woon Kim, Seung Yoon Park, In-San Kim

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Myoblast fusion is important for skeletal muscle formation. Even though the knowledge of myoblast fusion mechanism has accumulated over the years, the initial signal of fusion is yet to be elucidated. Our study reveals the novel function of a phosphatidylserine (PS) receptor, stabilin-2 (Stab2), in the modulation of myoblast fusion, through the recognition of PS exposed on myoblasts. During differentiation of myoblasts, Stab2 expression is higher than other PS receptors and is controlled by calcineurin/NFAT signaling on myoblasts. The forced expression of Stab2 results in an increase in myoblast fusion; genetic ablation of Stab2 in mice causes a reduction in muscle size, as a result of impaired myoblast fusion. After muscle injury, muscle regeneration is impaired in Stab2- deficient mice, resulting in small myofibers with fewer nuclei, which is due to reduction of fusion rather than defection of myoblast differentiation. The fusion-promoting role of Stab2 is dependent on its PS-binding motif, and the blocking of PS-Stab2 binding impairs cell-cell fusion on myoblasts. Given our previous finding that Stab2 recognizes PS exposed on apoptotic cells for sensing as an "eat-me" signal, we propose that PS-Stab2 binding is required for sensing of a "fuse-me" signal as the initial signal of myoblast fusion. [BMB Reports 2016; 49(6): 303-304].

Original languageEnglish
Pages (from-to)303-304
Number of pages2
JournalBMB reports
Volume49
Issue number6
Publication statusPublished - 2016 Jun 1

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Myoblasts
Phosphatidylserines
Electric fuses
Fusion reactions
Muscle
Muscles
Calcineurin
Cell Fusion
Ablation
Regeneration
Skeletal Muscle
Cells
Modulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Novel function of stabilin-2 in myoblast fusion : the recognition of extracellular phosphatidylserine as a "fuse-me" signal. / Kim, Go Woon; Park, Seung Yoon; Kim, In-San.

In: BMB reports, Vol. 49, No. 6, 01.06.2016, p. 303-304.

Research output: Contribution to journalComment/debate

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