Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Hye Sook Kim, Soon Wook Lee, Yoon Ji Choi, Sang Won Shin, Yeul Hong Kim, Min Sun Cho, Soon Nam Lee, Kyong Hwa Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalCancer Research and Treatment
Volume47
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

BRCA1 Gene
Lymphoma, Large B-Cell, Diffuse
Germ-Line Mutation
Ovarian Neoplasms
Breast Neoplasms
Frameshift Mutation
Mutation
Hematologic Neoplasms
Lymphoma

Keywords

  • BRCA1 gene
  • Breast neoplasms
  • Lymphoma
  • Ovarian neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma. / Kim, Hye Sook; Lee, Soon Wook; Choi, Yoon Ji; Shin, Sang Won; Kim, Yeul Hong; Cho, Min Sun; Lee, Soon Nam; Park, Kyong Hwa.

In: Cancer Research and Treatment, Vol. 47, No. 3, 2015, p. 534-538.

Research output: Contribution to journalArticle

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AU - Kim, Yeul Hong

AU - Cho, Min Sun

AU - Lee, Soon Nam

AU - Park, Kyong Hwa

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